Etiology of Acute Leukemias in Children

ISBN-13: 9783319057972 / Angielski / Twarda / 2016 / 320 str.

Juan Manuel Mejia-Arangure

Opis

By addressing the etiology of the disease, discussing from molecular biology until epidemiology and clinical manifestations, this book will guide present and future approaches, contributing for a better clinical management of leukemia in children.

Recenzje

"The purpose is to provide a broader view of the origins of childhood leukemia. ... The target audience is professionals working in the area of diagnosis and treatment of childhood leukemia, such as epidemiologists, molecular biologists, cellular biologists, pediatricians, and hematologists/oncologists interested in the field of acute leukemia. ... It is useful as a foundation for further discussion on the mechanisms by which these different factors interact to generate the ultimate result, acute leukemia." (Joseph Rosenthal, Doody's Book Reviews, July, 2016)

Spis treści

1. Acute leukemias - An introduction.- 2. Etiology and prevention of acute leukemias in children.- 3. Direct viral leukemogenesis hypothesis.- 4. Etiology of leukemia in children with Down syndrome.- 5. Origin of leukemia in children with Down syndrome.- 6. Model: Susceptibility, exposure and vulnerability period.- 7. Molecular origin of acute leukemias.- 8. When as environmental factor would be considered cause of acute leukemia in children.- 9. Early bone marrow hematopoietic differentiation in acute lymphoblastic leukemia.

O autorze

Physician (1990), MSc in Epidemiology (1994) and PhD in Clinical Epidemiology (2004) by the Universidad Nacional Autónoma de México. Dr. Mejia-Arangure serves as researcher at the Pediatric Hospital, National Medical Center “Century XXI” of the Instituto Mexicano del Seguro Social. He has 24 years of experience in research; his interests include investigating the etiology of acute leukemias in children. Dr. Mejia-Arangure has published more than 60 scientific articles, 10 book chapters and one book on clinical epidemiology of acute lymphoblastic leukemia. He has been reviewer for different journals, i.e. BMC Cancer, BMC Immunology, European Journal of Cancer Prevention, American Journal of Preventive Medicine, Archives of Medical Research, BMJ Open, among others. Dr. Mejia-Arangure is also member of different International Societies and have received many Grants to support his research.