Estrogens, Progestins, and Their Antagonists: Health Issues

ISBN-13: 9780817638542 / Angielski / Twarda / 1996 / 328 str.

Edward J. Pavlik

Opis

v. K. Moudgil, Series Editor INTRODUCTION TO VOLUME 2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xiii Edward J Pavlik ABOUT VOLUME 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xvi Edward J Pavlik CONTRIBUTORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xix Part I: ESTROGEN AND PROGESTIN PHYSIOLOGICAL FuNCTION 1. Pituitary and Brain Actions of Estrogen and Progesterone in the Regulation of Primate Prolactin Secretion. . . . . . . . . . . . . . . . . . . . . . . 3 C. L. Bethea, S. G. Kohama, and M. Pecins-Thompson 2. Saccharomyces cerevisiae As a Model System to Study Steroid Hormone Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . " 47 Brandee L. Wagner and Donald P McDonnell 3. Physiological Findings from Transgenic Mouse Models with Altered Levels of Estrogen Receptor Expression. . . . . . . . . . . . . . . . . . . . 69 John F Couse, Vicki L. Davis, and Kenneth S. Korach Part II: MOLECULAR BIOLOGY OF STEROID RECEPTORS AND GENE EXPRESSION 4. New Models and Insights in Steroid Hormone Action . . . . . . . . . . . . . . . . 101 Lisa L. Wei 5. A Role for Progesterone in Multidrug Resistance . . . . . . . . . . . . . . . . . . . . 123 Shyamali Mallick and Susan Band Horwitz 6. Dominant Negative Activity by Estrogen and Progesterone Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153 Paul M. Yen 7. Estrogen and Progesterone Receptors in Human Endometrial Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169 Kian Behbakht and Jeff Boyd x Contents Part m: FACTORS ENHANCING RECEPTOR FuNCllON 8. Facilitated Binding of Steroid Hormone Receptors to Target DNA by the Chromatin High-Mobility Group Protein-1: Protein Manipulation of DNA Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191 Dean P. Edwards and Paul Prendergast 9. Use of FK506 and Its Analogs in Studying Progesterone Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217 Ping-Kaung Ku Tai and Lee E. Faber KEYWORD INDEX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231 Foreword These two volumes on Estrogens, Progestins, and Their Antagonists repre sent a thematic extension of the series, Hormones in Health and Disease."

Spis treści

I: New Applications and Concepts Involving Estrogens and Progestins.- 1. Benefits and Risks of Hormone Replacement Therapy.- 2. Phytoestrogen Effects in Humans Relative to Risk for Cardiovascular Disease, Breast Cancer, Osteoporosis, and Menopausal Symptoms.- 3. Dietary Indoles with Antiestrogenic Activity in Common Vegetables and Their Implications.- 4. Treatment for Infertility and Risk of Female Cancers.- 5. Antiestrogen Resistance in Human Breast Cancer.- 6. Evolving Therapies for Prostatic Carcinoma, Encompassing Orchiectomy, Estrogens, and Estramustine.- 7. Regulatory Aspects of Estrogens and Progestins in Human Food: Past, Present, and Future.- II: Novel Hormonal Ligands.- 8. Estrogen and Progestin Radiopharmaceuticals for Imaging Breast Cancer.- 9. The Utility of Fluorescent Estrogens for Receptor Imaging.- 10. Comparative Review of Recently Introduced Oral Contraceptives Containing Norgestimate, Desogestrel and Gestodene and Older Oral Contraceptives.- 11. Antiprogestins: Past, Present, and Future.- Keyword Index.