Estrogen Effects on Traumatic Brain Injury: Mechanisms of Neuroprotection and Repair

ISBN-13: 9780128014790 / Angielski / Twarda / 2015 / 172 str.

Kelli A. Duncan

Opis

This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain Injury is of great importance to teachers, researchers, and clinicians interested in the role that estrogens play following traumatic brain injury.

• Written to provide a foundational view of estrogens as neuroprotectors in TBI, appropriate for both researchers and advanced students
• Data Analysis boxes in each chapter help with data interpretation and offer guidelines on how best to understand results.
• A multidisciplinary approach to the methods, issues, empirical findings in the field of estrogen mediated neuroprotection.
• Detailed focus on how studies relate and build upon each other and the ways different methods of analysis inform each other.
• Written to provide clinicians with new and developing treatment options for patients in their field.

Spis treści

1. Historical Antecedents
2. Estrogen Actions in the Brain
3. Induction of Estrogen Response Following Injury
4. Astrocytic Aromatization and Injury
5. Aromatase and Estrogens: Involvement in Constitutive and Regenerative Neurogenesis in Adult Zebrafish
6. Neuroprotection by Exogenous Estrogenic Compounds Following Traumatic Brain Injury
7. Neuroprotective Effects of Estrogen Following Neural Injury
8. Neuroprotection with Estradiol in Experimental Perinatal Asphyxia: A New Approach
9. Cerebrovascular Stroke: Sex Differences and the Impact of Estrogens
10. Concluding Statements and Current Challenges

O autorze

Kelli A. Duncan holds a Ph.D. in biology from Georgia State University (specializing in Neurobiology and Behavior). Dr. Duncan has over 10 years of experience working in behavioral neuroendocrinology and was awarded the Society for Behavioral Neuroendocrinology Young Investigator award. She is an expert in the area of hormone and immune effects on nervous tissue, specifically the effects of penetrating injury in the zebra finch brain, and was the first to identify a role for inflammation in the upregulation of glial aromatase in any vertebrate. Dr. Duncan is an Assistant Professor of biology and Neuroscience and behavior at Vassar College.