"This is a comprehensive review of the problem of restenosis, from the basic science to clinical management. ... The audience includes interventional cardiology fellows and interventional cardiologists. The book describes the difficulties that cardiologists face trying to prevent and manage restenosis. ... Each chapter includes extensive references. This is a complete, state-of-the-art review of restenosis, covering all aspects of restenosis from pathophysiology to therapeutic management. The authors are leaders in interventional cardiology with extensive clinical experience in the field." (Adriana Maria Rosario, Doody's Review Service, December, 2007)
"A multiauthored, comprehensive compendium of virtually all aspects of the restenotic process after balloon- or stent-induced arterial injury. ... The text is written by a blueribbon panel of authors who provide an in-depth coverage of the topics. Many of the clinical chapters offer an excellent historical perspective on the problem of restenotis. ... Recommended Readership: Interventional (clinical and research) cardiologists and interventional fellows." (John F. Bresnahan, Mayo Clinic Proceedings, Vol. 83 (4), April, 2008)
Essentials of Restenosis for the Interventional Cardiologist
Table of Contents:
Part A. Introduction
Henricus J. Duckers
Caroline Cheng
Dennie Tempel
Patrick W. Serruys
Part B. Pathophysiology and Diagnosis
Chapter:
1. Epidemiology and Pathogenesis of Restenosis Randolph L. Geary
Alexander W. Clowes
2. Clinical Presentation of Restenosis Ganesh Manoharan
Giedrius Davidavicius
William Wijns
3. Pathologic Anatomy of Restenosis Renu Virmani
Frank D. Kolodgie
Aloke V. Finn
Herman K. Gold
4. The Influence of Shear Stress on Restenosis Attila Thury
Cornelis J. Slager et al.
5. Role of the Immune System in the
Pathogenesis of Vascular Proliferative Disease Jon D. Laman
Burkhard Ludewig
6. Animal Restenosis Models.
From the “Ideal Model� to the “Ideal Study� Arturo G. Touchard
Robert S. Schwartz
Part C. Genetic base of restenosis
Chapter:
7. The Genomics of Restenosis Thomas W. Johnson
Karl R. Karsch
8. Gene Expression Profiling and Restenosis Dietlind Zohlnhöfer
Franz-Josef Neumann
9. Proteomics and Restenosis Santhi K. Ganesh
Elizabeth G. Nabel
10. Contribution of circulating Progenitor Cells to
Vascular Repair and Lesion Formation. Masataka Sata
Kenneth Walsh
11. Cell Cycle Regulation in Vascular
Proliferative Diseases Andrew Wragg
Manfred Boehm
12. Arterial Remodelling Gerard Pasterkamp
Bradley H. Strauss
Dominique de Kleijn
13. The role of eNOS in vascular diseases Alexey Kuroedov
Francesco Cosentino
Felix C. Tanner
Thomas Lüscher
Part D. Diagnostics of Restenosis
Chapter:
14. The use of pressure gradient analysis in the
diagnosis of restenosis Volker Klaus
Nico N.H.J. Pijls
15. The Use of Radio Isotopes in the Diagnosis
ofVascular Proliferative Disease Giedrius Davidavicius
Ganesh Manoharan
William Wijns
16. Magnetic resonance imaging for restenosis Robert Jan M. van
Geuns
Timo Baks
17. Coronary Imaging with Multislice Spiral
Computed Tomography Koen Nieman
Part E. Therapy of Restenosis
Chapter:
18. Pharmacotherapy of Restenosis Pim J. de Feyter
Georgios Sianos
19. Brachytherapy Ron Waksman
20. Pre-clinical Data of Eluting Stents Antonio Colombo
Alaide Chieffo
21. Clinical Data of Eluting Stents Marco A. Costa
Alexandre Abizaid
Amanda G.M.R. Sousa
Eduardo Sousa
22. Biodegradable stents Takafumi Tsuji
Hideo Tamai
Keiji Igaki
Part F. Biotechnology in the Treatment of Restenosis
Chapter:
23. Vascular Gene Therapy Gurpreet S. Sandhu
Robert D. Simari
24. Antisense and ODN transcription factors
in the treatment of Vascular Proliferative Disease Nicholas Kipshidze
Mykola Tsapenko
George Dangas
Pat Iversen
25. Cell Cycle Approaches to the
Treatment of In-stent Restenosis Elizabeth G. Nabel
26. Local Gene and Cell Delivery Devices Ravish Sachar
Eric J. Topol
Essentials of Restenosis provides the practicing cardiologists and biologists an elaborate review of the current advances in the field. Authors explore the process of restenosis from bench to bedside, encompassing in equal detail the newest scientific findings of the biological mechanisms as well as the progression in development of diagnostics and treatments. The volume also provides the reader with a basic understanding of the biological process and the latest diagnostics and treatments of the disease, with an up-to-date detailed discussion of the most important recent findings.
Leading interventional cardiologists, including Patrick Serruys, Eric Topol, David Holmes, Thomas Luscher and others provide the gold-standard reference on the treatment of restenosis (coronary artery blockage) for interventional cardiologists. Dr. Serruys, who pioneered the use of drug-eluting stents, and other pioneers in the field cover everything from non-invasive imaging, to eluting stents, to brachytherapy through to the latest molecular biology-based treatments including antisense, stem cells and gene therapy, making this an essential reference for all interventional cardiologists. Thorough chapters discuss the current understanding on the pathophysiology, molecular and genetic base, and methods of diagnosis of restenosis, and present the current state-of-the-art management, including pharmacotherapy and interventional percutaneous approaches using brachytherapy, gene therapy and drug eluting stent technology.
All this makes Essentials of Restenosis an excellent handbook for introducing new intervention cardiologists, vascular biologists, and medical students into the subject. This text provides the reader with a complete overview of the basic and applied knowledge of restenosis, leading to better insight and decision-making in clinical practice.