'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

ISBN-13: 9789811510663 / Angielski / Twarda / 2020 / 499 str.

Nosheen Masood; Saima Shakil Malik

Spis treści

Chapter 1. Introduction.- Chapter 1.1. Overview of cancer genomics.- Chapter 1.2. Organization and variations in human genome.- Chapter 1.3. Genomic technologies (Sequencing, next generation sequencing, biomarkers, DNA micro-arrays, tissue microarrays).- Chapter 1.4. Metabolic changes and their characterization.-Chapter 1.5. Sequencing in cancer prognosis and treatment.- Chapter 1.6. Unravelling genomics targets of small molecules.- Chapter 1.7. Application of CRISPR-Cas 9 system in genomic editing in cancer.- Chapter 1.8. Role of nanomedicine in cancer detection and inhibition (drug delivery systems).- Chapter 1.9. Clinical application of cancer genomics.- Chapter 2. Cancer Metastasis.- Chapter 2.1. Role of Genomic instability and cancer metastasis.- Chapter 2.2. Tumour dormancy and metastasis.- Chapter 2.3. Response of DNA damage repair pathways.- Chapter 2.4. Micro-environmental control.- Chapter 2.5. Role of mechanotransduction and immunomodulation in cancer metastasis and genomic instability.- Chapter 2.6. Synthetic genetic strategies.- Chapter 3. Role of Transcriptomics in cancer treatment strategies.- Chapter 3.1. Cancer transcriptome sequencing and analysis.- Chapter 3.2. Association of Transcriptomics with treatment strategies.- Chapter 3.3. Importance of microRNAs in cancer.- Chapter 3.4. RNA-seq and precision medicine.- Chapter 3.5. Translational genomics.- Chapter 3.6. Genomic medicine.- Chapter 3.7. Clinical oncology.- Chapter 3.8.  Role of non-coding sequence variants in cancer. Chapter 3.9. Translational research in oncology.- Chapter 3.10. Analysis of proteomic approaches for cancer treatments.- Chapter 3.11. Concepts of personalized medicine based on proteomics. Chapter 4. Computational approaches.- Chapter 4.1. System biology and system medicine.- Chapter 4.2. Computational analysis.- Chapter 4.3. Mathematical modelling and genomic medicine.- Chapter 4.4. Prognostic and predictive methods towards precision medicine. Chapter 5. Biostatistics and clinical oncology.- Chapter 5.1.Variables and their distribution.- Chapter 5.2. Sample size calculations, study designs, regression analysis, survival analysis (OS and PFS/TTS).- Chapter 5.3. Randomized clinical trials, meta-analysis, statistical models.- Chapter 5.4. Challenges faced during analysing data on quality of life in cancer patients.- Chapter 6. Pharmacogenomics in cancer.- Chapter 6.1. Importance of pharmacogenomics,.- Chapter 6.2. Linking cancer genomics with pharmacological factors.- Chapter 6.3. Peads pharmacogenomics and cancer.- Chapter 6.4. Future of pharmacogenomics in cancer.- Chapter 7. Case studies. -Chapter 7.1. Case studies on the role of precision medicine in cancer.- Chapter 7.2. Current challenges on genomic research.- Chapter 7.3. Future perspectives of cancer genomics.

O autorze

Dr. Nosheen Masood is currently working as an Assistant Professor at the Department of Biotechnology, Fatima Jinnah Women University, Rawalpindi, Pakistan. She completed her PhD in Human Molecular Genetics at the Department of Biosciences at COMSATS University, Islamabad, Pakistan . Her main research interests include molecular biology and cancer genetics, with a focus on epidemiological studies, risk assessment, genomic analysis, immunohistochemistry-based diagnostics and protein-protein interactions. She has been received various prestigious awards, notably, the Research Productivity Award 2014-2015 from the Pakistan Council of Science and Technology (PCST) category D, and Research Productivity Awards from COMSATS Institute of Information Technology for six consecutive years from 2010 to15. She has served as a reviewer for a number of international journals. She has teaching experience in biotechnology, molecular biology, comparative genomics, environmental biology, regulation of gene expression and molecular evolution.

She has published a number of research articles in respected, peer-reviewed international journals and authored or co-authored various book chapters.

Saima Shakil Malik is presently working as the Scientific Officer at Armed Forces Institute of Pathology, Rawalpindi, Pakistan. She has obtained her Ph.D. from the Department of Biotechnology, Fatima Jinnah Women University, Rawalpindi, Pakistan. Previously, she has worked as a visiting researcher at the School of Cellular and Molecular Medicine at University of Bristol, UK. Her research interests are focused on the cancer genetics and molecular diagnostics. She has teaching experience in biotechnology, molecular biology and biostatistics. She has numerous publications in internationally reputed journals and authored book chapters.

Blurb

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies.

It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research.

Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.