Erythrocytes as Drug Carriers in Medicine

ISBN-13: 9781489900463 / Angielski / Miękka / 2013 / 150 str.

Ulrich Sprandel;James L. Way

Opis

The sixth meeting on the use of resealed annealed red blood cells was held in Irsee, Germany by the International Society for the Use of Resealed Erythrocytes (ISURE) on July 25-28, 1996. Although earlier meetings focused on the technology toward develop- ment of methods and standardization for efficient, consistent encapsulation, most of the present studies now are directed toward the application use of these carrier blood cells. Basic studies now have been directed toward exploration of commercial applications. In- deed, clinical trials were initiated to evaluate the dose-response curves employing L- asparagenase in human patients. Also, studies have shown the use of thrombolytic agent in erythrocyte carriers with the use of human red blood cells to provide a new conceptual ap- proach in thrombolytic therapy to prevent thrombosis in individuals with higher risk fac- tors. For example, with the use of carrier red blood cells, the thrombolytic agents will have a greater potential of acting on clot formation without systemic activation and thus lower the risk of hemorrhage, which is always prevalent in the thrombolytic therapy.

Spis treści

A Model for the Assessment of Human Recombinant Interleukin (rIL2) Coated Erythrocytes as a Delivery System for Immunotherapy; J. DeLoach. Human Recombinant Interleukin 2 binds to Mouse Red Blood Cells via the Erythropoiet in Receptor; J. DeLoach. In Vivo Survival of Human Energy-Replete Carrier Erythrocytes; M.D. Bain. The Entrapment of Polyethylene Glycolconjugated Adenosine Deaminase (Pegademase) and Native Adenosine Deaminase in Human Carrier Erythrocytes; B.E. Bax, M.D. Bain. Use of Erythrocytes as a New Route of Administration of Fibrinolytic Agents. Preliminary Results; C. Ropars. Slow Release of Azidothymidine from Azidothymidine Homodinucleotide-Loaded Human Erythrocytes; M. Giovine. Erythrocyte-Based Targeted Delivery of an Azidothymidine Homodinucleotide Conferring Protection to Macrophages Against Retroviral Infection; A. De Flora. Mannose-Terminated Glucocerebrosidase (Alglucerase) Entrapped in Human Carrier Erythrocytes; B.E. Bax, M.D. Bain. Macrophage Protection by Nucleoside and Nucleotide Analogue Administration; L. Rossi. Inhibition of Murine Aids by Combination of AZT and Dideoxycytodine 5¿-Triphosphate; A. Fraternale. 9 Additional Articles. Index.