Epilepsy: Mechanisms, Models, and Translational Perspectives

ISBN-13: 9780367383909 / Angielski / Miękka / 2019 / 684 str.

Jong Rho; Raman Sankar; Carl E. Stafstrom

Opis

Written for researchers and clinicians in neurology and neuroscience, this text offers a bridge across the so-called translational divide, to cover innovative treatment strategies that, while based on scientific principles, have yet to be tested rigorously in clinical settings. The text features the contributions of leading researchers in adult and pediatric epilepsy who cover a range of topics including gene therapy, metabolic regulation, and neuroprotective strategies. It offers an understanding of the pathogenesis and mechanisms of various epilepsy syndromes, highlights therapies with the greatest potential, and identifies challenges common to researchers.

Spis treści

Scientific Foundations. Antiepileptic Drugs. Epilepsy Surgery. Alternative Therapies. Other Modulators of the Epileptic State. The Future of Epilepsy Therapy.

O autorze

Jong M. Rho, MD, is a senior staff scientist at the Barrow Neurological Institute and St. Joseph’s Hospital & Medical Center in Phoenix, Arizona. After obtaining an undergraduate degree in molecular biophysics and biochemistry at Yale University, Dr. Rho received his medical degree from the University of Cincinnati. Following a pediatric residency at the University of Southern California Children’s Hospital of Los Angeles and a neurology residency at the University of California, Los Angeles (UCLA), School of Medicine, he completed fellowships in pediatric neurology at the UCLA School of Medicine and in neuropharmacology at the National Institutes of Health (NIH). Dr. Rho’s main research interests are the mechanisms underlying the anticonvulsant and neuroprotective effects of the ketogenic diet, neuropharmacology of anticonvulsant compounds, and the study of surgically respected human epileptic tissue. His research activities have been sponsored by several NIH research grants, as well as a variety of intramural and extramural public and private sector sources. Dr. Rho has served on the editorial boards of Epilepsia and Epilepsy Currents and has been a regular reviewer for research grants submitted to the NIH. In addition to an extensive list of publications in basic science and pediatric neurology peer-reviewed journals, Dr. Rho has written numerous book chapters and edited several books and is a popular national and international guest lecturer.

Raman Sankar, MD, PhD, is a professor of neurology and pediatrics and chief of pediatric neurology at the David Geffen School of Medicine at UCLA. He holds the Rubin Brown Distinguished Chair in Pediatric Neurology. Dr. Sankar obtained his doctorate from the University of Washington in medicinal chemistry and was involved in teaching and research for several years prior to entering Tulane Medical School, where he obtained his medical degree. He trained in p