Epigenetics and Neuroendocrinology: Clinical Focus on Psychiatry, Volume 1

ISBN-13: 9783319796369 / Angielski / Miękka / 2018 / 264 str.

Dietmar Spengler; Elisabeth Binder

Recenzje

"The intended audience ... includes researchers studying epigenetics in regard to stress-related psychiatric disorders such post-traumatic stress disorder, anxiety disorders, mood disorders, and eating disorders. Clinicians who would like to stay informed about this interesting research would also benefit from reading this book. ... This is an interesting and very informative book on epigenetics and neuroendocrinology in relation to psychiatric disorders and the brain and behavior. ... it is a welcome addition to the psychiatric literature." (Michael Joel Schrift, Doody's Book Reviews, August, 2016)

Spis treści

Foreword by Dietmar Spengler & Elisabeth Binder.- Part I, Epigenetics And The Stress System.- I.1 From vulnerability to neurotoxicity: A developmental approach to the effects of stress on brain and behavior .- I.2 Dynamic regulation of chromatin modification and transcription by GR and the steroid receptors .- I.3 NR receptor coactivators.- I.4 Glucocorticoid-dependent epigenetic regulation of Fkbp5.- I.5 Epigenetic programming of the HPA axis by early-life adversity.- I.6 Epigenetic programming of hypothalamic Pomc regulates feeding and obesity.- I.7 Effects of maternal care in monkeys.- I.8 Stress, transposons and the brain epigenome.- Part II; Epigenetics And Sexual Differentiation.- II.1 Neuroepigenetics of sexual differentiation of brain and behavior.- II.2 Differential regulation of androgen receptor and DNA methylation in songbirds.- II.3 chapter title "GnRH gene/Kiss gene, sexual dimorphism, puberty.            

Blurb

The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.