Epigenetics and Human Reproduction

ISBN-13: 9783642147722 / Angielski / Twarda / 2010 / 372 str.

Sophie Rousseaux; Saadi Khochbin

Opis

Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the 'Epigenetics and Human Health' series discusses the role of epigenetics in human reproduction. The book presents epigenetic transitions that are important at defined stages of gametogenesis and during meiosis. Finally, the authors discusses how in vitro manipulation and culture in assisted reproduction can epigenetically perturb germ cells, and how this can trigger disease phenotypes in the next generation. Conceived towards advanced students, medical professionals and research scientists, this is the first comprehensive textbook on this topic that will serve as a valuable reference during the years to come.

Spis treści

Preface – B. Jegou.- Part 1 - Medical aspects and questions raised on the molecular basis of epigenome involvement in reproduction.- Chapter 1: Potential Epigenetic Consequences Associated with Assisted Reproduction.- Chapter 2: Germ cell cancer, testicular dysgenesis syndrome and epigenetics.- Chapter 3: Medical implications of sperm nuclear quality.- Chapter 4: Gene expression/phenotypic abnormalities in placental tissues of sheep clones: insurmountable block in cloning progress? .- Part 2 - Fundamental aspects of genome and epigenome reprogramming during gametogenesis.- Chapter 5: Epigenetic reprogramming associated with primordial germ cell development.- Chapter 6: Epigenetic factors and regulation of meiotic recombination in mammals.- Chapter 7: Meiotic pairing of homologous chromosomes and silencing of heterologous regions.- Chapter 8: Histone variants during gametogenesis and early development.- Chapter 9: Genome organization by vertebrate sperm nuclear basic proteins (SNBPs).- Chapter 10: Epigenetics in Male Reproduction: A Practical Introduction to the Informatics of Next Generation Sequencing.- Part 3 – Re-organization of nuclear compartments during gametogenesis.- Chapter 11: organisation of chromosomes during spermatogenesis and in mature sperm.- Chapter 12: Lamins and spermatogenesis.- Part 4 - Fundamental aspects of gene expression regulation during gametogenesis.- Chapter 13: Specific transcription regulatory mechanisms of male germ cells.- Chapter 14: The Chromatoid Body: a Specialized RNA Granule of Male Germ Cells.- Chapter 15: Sperm RNA: reading the hidden message.- Subject index

Blurb

Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction. The book presents epigenetic transitions that are important at defined stages of gametogenesis and during meiosis. Several of the sixteen chapters written by experts in the field cover fundamental concepts discovered through cellular and biochemical work and from research on animal models. In other chapters, key examples are provided of how disruption of these mechanisms affects germ cell development and fertility, and contributes to the germinal cancers. Finally, the book discusses how in vitro manipulation and culture in assisted reproduction can epigenetically perturb germ cells, and how this can trigger disease phenotypes in the next generation. Conceived towards advanced students, medical professionals and research scientists, this is the first comprehensive textbook on this topic that will serve as a valuable reference during the years to come