Epigenetics - A Different Way of Looking at Genetics

ISBN-13: 9783319271842 / Angielski / Twarda / 2016 / 254 str.

Walter Doerfler; Petra Bohm

Opis

This book presents epigenetics research as a new way of looking at genetics. Topics range from basic epigenetics mechanisms to development of cells and organisms and the biological basis of diseases. In addition the book focuses on immunology and the role of viruses in epigenetics. The last part of the book highlights proteins and peptides as epigenetic modulators.

Spis treści

Preface.- Formation of Bacterial Lineages in Salmonella enterica by Epigenetic Mechanisms.- Non-coding RNAs and Chromatin Modifications in the Developmental Control of Imprinted Genes.- Lymphocyte Identity and Genomic Switches.- Epigenetic Imprinting of Immunological Memory.- Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity.- Epigenetic Alterations of Viral and Cellular Genomes in EBV Infected Cells.- Epigenetic Destabilization by Inserting Foreign DNA Into Mammalian Genomes: Oncogenesis and Evolution.- What Mechanisms Induce Methylation of FMR1 Gene Full Mutation? A Still Unanswered Question.- Silencing of Human Cytomegalovirus Gene Expression Mediated by Components of PML Nuclear Bodies.- Azanucleoside DNA Methyltransferase Inhibitor Drugs: Update on Clinical Applications in Myelodysplastic Syndromes and Acute Myeloid Leukemia.- Oxidative Stress and Cancer Epigenomics.- Glossary.

O autorze

Walter Doerfler: • 1981: Aronson-Preis, Berlin • 1984: Robert-Koch-Preis, Bonn • 1986–1992: Senat der Deutschen Forschungsgemeinschaft, Bonn • 1997: Mitglied Deutschen Akademie der Naturforscher Leopoldina, Halle • 2007: Fellow of the American Association for the Advancement of Science (AAAS) • 2013: Löffler Frosch Medaille der Gesellschaft für Virologie