Epigenetic Technological Applications

ISBN-13: 9780128010808 / Angielski / Twarda / 2015 / 516 str.

Y Zheng

Opis

Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm.

• Discusses technologies that are critical for epigenetic research and application
• Includes epigenetic applications for state-of-the-art technologies
• Contains a global perspective on the future of epigenetics

Spis treści

Preface1. Introduction of the Epigenetic Technologies2. Technologies for the Measurement and Mapping of Genomic 5-methylcytosine and 5-hydroxymethylcytosine3. Technologies to Map DNA 5hC and 5fC and 5caC4. Application of Mass Spectrometry in Translational Epigenetics5. Techniques Analyzing Chromatin Modifications at Specific Single Loci6. Comprehensive Analysis of Mammalian Linker-histone Variants and Their Mutants7. Crystallography-based Mechanistic Insights into Epigenetic Regulation8. Chemical and Genetic Approaches to Study Histone Modifications9. Peptide Microarrays for Profiling of Epigenetic Targets10. Current Methods for Methylome Profiling11. Bioinformatics and Biostatistics for Mining Epigenetic Disease Markers and Targets12. Computational Modeling to Elucidate Molecular Mechanisms of Epigenetic Memory13. DNA Methyltransferase Inhibitors for Cancer Therapy14. Histone Acetyltransferases: Enzymes, Assays, and Inhibitors15. In Vitro Histone Deacetylase Activity Screening: Making a Case for Better Assays 16. Enzymatic Assays of Histone Methyltransferase Enzymes17. Histone Methyltransferase Inhibitors for Cancer Therapy18. Discovery of Histone Demethylase Inhibitors19. Fluorescent Technologies in Studying Dynamics of Histone Modification20. Animal Model Study of Epigenetic Inhibitors