Epigenetic Regulation of Lymphocyte Development

ISBN-13: 9783642241024 / Angielski / Twarda / 2012 / 194 str.

Cornelis Murre

Opis

The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.

Spis treści

Preface.- Roles of lineage-determining transcription factors in establishing open chromatin – lessons from high-throughput studies.- B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1.- Epigenetic features that regulate IgH locus recombination and expression.- Local and global epigenetic regulation of V(D)J recombination.- Genetic and Epigenetic Regulation of TCRbeta Gene Assembly.- T-cell identity and epigenetic memory.- Encoding stability versus flexibility:  Lessons learned from examining epigenetics in T helper cell differentiation.- The epigenetic landscape of lineage choice: lessons from the heritability of Cd4 and Cd8 expression.-  Subject Index

Blurb

Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.