Enzyme Biocatalysis: Principles and Applications

ISBN-13: 9781402083600 / Angielski / Twarda / 2008 / 392 str.

Illanes, Andrés

Opis

This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.

Recenzje

Aus den Rezensionen:

"... Zielgruppe von 'Enzyme Biocatalysis' sind vor allem PhD-Studierende und Wissenschaftler, die sich in die Biokatalyse einlesen oder vorhaben, sich tiefer mit der Materie zu befassen. Es empfiehlt sich als Anleitung für spezifische anwendungsorientierte Fragestellungen und Nachschlagewerk für kinetische Berechnungen." (in: chemiereport.at, 2008, Issue 8, S. 41)

Spis treści

1. Introduction (Andrés Illanes)
2. Enzyme Production (Andrés Illanes)
3. Homogeneous Enzyme Kinetics (Andres Illanes, Claudia Altamirano, Lorena Wilson)
4. Heterogeneous Enzyme Kinetics (Andres Illanes, Roberto Fernández-Lafuente, José Manuel Guisán, Lorena Wilson)
5. Enzyme Reactors (Andrés Illanes, Claudia Altamirano)
6. Study Cases of Enzymatic Processes
6.1. Proteases as catalysts for peptide synthesis (Sonia Barberis, Fanny Guzmán, Josep López-Santín)
6.2. Synthesis of ß-lactam antibiotics with penicillin acylases (Andrés Illanes, Lorena Wilson)
6.3. Chimioselective esterification of wood sterols with lipases (Gregorio Alvaro, Andrés Illanes)
6.4. Oxidoreductases as powerful biocatalysts for green chemistry José Manuel Guisán, Roberto Fernández-Lafuente, Lorena Wilson, César Mateo)
6.5. Use of aldolases for asymmetric synthesis (Josep López-Santín, Gregorio Alvaro, Pere Clapés)
6.6. Application of enzymatic reactors for the degradation of highly and poorly soluble recalcitrant compounds (Juan M. Lema et al.)