Environmental Factors in Neurodegenerative Diseases: Volume 1

ISBN-13: 9780128127643 / Angielski / Miękka / 2017 / 290 str.

Michael Aschner; Lucio G. Costa

Opis

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson's disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike.

• Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology
• Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers
• Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America
• Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Spis treści

1. Traffic-Related Air Pollution and Neurodegenerative Diseases: Epidemiological and Experimental Evidence, and Potential Underlying Mechanisms Lucio G. Costa 2. The Catecholaminergic Neurotransmitter System in Methylmercury-Induced Neurotoxicity Marcelo Farina, Michael Aschner and João B.T. da Rocha 3. Pesticides and Parkinson's Disease: Current Experimental and Epidemiological Evidence Samuel M. Goldman, Ruth E. Musgrove, Sarah A. Jewell and Donato A. Di Monte 4. Metals and Circadian Rhythms Nancy L. Parmalee and Michael Aschner 5. Aluminum and Neurodegenerative Diseases Stephen C. Bondy and Arezoo Campbell 6. Manganese Neurodegeneration David C. Dorman 7. Roles of Microglia in Inflammation-Mediated Neurodegeneration: Models, Mechanisms, and Therapeutic Interventions for Parkinson's Disease Hui-Ming Gao, Dezhen Tu, Yun Gao, Qiyao Liu, Ru Yang, Yue Liu, Tian Guan and Jau-Shyong Hong 8. Mitochondrial Dynamics in Neurodegenerative Diseases Jennifer Pinnell and Kim Tieu 9. Food Plant Chemicals Linked With Neurological and Neurodegenerative Disease Peter S. Spencer and Valerie S. Palmer

O autorze

Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control), and is a member of the Neurotoxicology and Alcohol study section (NIH). Research in our lab focuses on the following topics: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of MeHg uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg's neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. Our studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences. Dr. Lucio G. Costa is Professor of Toxicology at the University of Washington in Seattle, and of Pharmacology/Toxicology at the University of Parma Medical School. He received a doctorate in Pharmacology from the University of Milano in 1977, and was a postdoctoral fellow at the University of Texas at Houston. He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various award for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. He serves in various editorial capacities for several toxicology journals, and is an active manuscript and grant reviewer. Dr. Costa has been the member of dozens of panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has chaired and/or organized symposia at scientific meetings in the United States and internationally. He has been teaching classes in the area of toxicology, neurotoxicology and pharmacology to graduate and medical students for 30 years. He keeps an active research program in the area of neurotoxicology.