Enhancement of solubility and dissolution rate of Griseofulvin

ISBN-13: 9786202514125 / Angielski / Miękka / 2020 / 96 str.

Pankaj Jadhav; Satwashila Kadam

Opis

In the recent years, the interest in micron and submicron systems in pharmacy as surged. Micron system comes in range of mim and submicron in nm. Typically colloid is an intermediates size between molecular range and coarse range. There has been a considerable research interest in the area of drug delivery using particulate systems. Particulate systems used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. Griseofulvin is an important agent in the treatment of dermatophytosis. Results of present work lead to a conclusion that reduced size of the drug particles with presence of the surfactants and polymers on the surface of griseofulvin microparticles are responsible for meteoric rise in solubility and dissolution velocity. Surfactants play an important role in the solubility of the drugs by increasing the wettability due to adsorption on the surfaces. Microparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules due to increased surface area by several times.

O autorze

Jadhav, Pankaj
I am currently working as an Assistant Professor at Annasaheb Dange College of B. Pharmacy, Ashta, Sangli. I have experience of undergraduate and postgraduate teacher in pharmacy for 10 years. There are 04 books and 20 papers in national and international reputed journals to my credit.