Enhanced Dielectrophoretic Enrichment of Nanoparticles Using a Nanotip : Nanoengineering for Medicine and Biology

ISBN-13: 9783846591291 / Angielski / Miękka / 2011 / 88 str.

Hong (Woon-Hong) Yeo

Opis

Enhanced dielectrophoretic (DEP) enrichment of nanoparticles (NPs) using a nanotip was studied through numerical computation and experiment. Fundamentals of the NP enrichment mechanism were studied through the calculation of DEP-, and Brownian motion forces. The DEP effective range for Au NP enrichment was determined through the comparison of force magnitude of DEP- and Brownian motion forces. The studied NP enrichment mechanism was then applied to specifically enrich target-oligonucleotides through affinity-binding force. In the experiment, the optimal enrichment condition was found for ultimate sensitivity of the nanotip. In addition, the size-specific enrichment mechanism was investigated through the study of DEP, capillary action, and viscosity. In the experiment, the size-specific enrichment mechanism was verified by using polystyrene nanospheres. As an application study, the NP enrichment mechanism was used to enrich and capture T7 viral particles with a nanotip. The experimental result demonstrated the successful capture of T7 viruses onto a nanotip with an AC electric field. The nanotip-based enrichment method showed the highly sensitive detection of T7 viruses.

O autorze

The author was born in 1980, South Korea. He received a B.S. from Inha University, South Korea, and Ph.D. from the University of Washington at Seattle, USA. Currently he is a Postdoctoral Research Associate at the University of Illinois at Urbana-Champaign. His research interests are Bio-integrated electronics and Nano/biomedicine.