Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol

ISBN-13: 9780081017500 / Angielski / Twarda / 2018 / 404 str.

Anilkumar Parambath

Opis

Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field.

• Provides a self-contained work for the field of biomaterials for drug delivery
• Summarizes the current knowledge on PEGylation and strategies for bypassing it
• Presents research on an important, though under-represented issue in biomaterials
• Written by a world-class team of research scientists, engineers and clinicians

Spis treści

1. PEGylated 'stealth' liposomes
2. PEGylated proteins
3. PEGylation and anti-PEG antibodies
4. Poly (zwitterions)
5. Poly (glycerols)
6. Poly (oxazolines)
7. Poly (aminoacids)
8. Poly (acylamides) and related systems
9. Poly (vinylpyrrolidones)
10. Sugar based systems (trehalose)
11. Polypeptide alternatives (PASylation and XTen) to PEG
12. DDS based on non-immunogenic biopolymers
13. Non-PEGylated nanoparticles
14. Summary and future perspectives

O autorze

Dr Anilkumar Parambath is Senior Manager and Head of Capsules Product R&D, ACG Capsules, Mumbai, India. Prior to this he was a Principal Investigator for Performance and Specialty Materials at Syngene International Ltd, Bangalore India, where he worked on developing various elastomers, silicones, acrylics and other polymers for biomedical applications. He completed his PhD in Chemistry (Polymer Science) at the University of Kerala, India, and spend 7 years conducting post-doctoral research at Clemson University, USA, French atomic Energy Commission (CEA), France, and the University of British Columbia, Canada. He has successfully led RnD programs of several innovation initiatives in academic and industry settings. Dr. Parambath has edited two books on polymer biomaterials in drug delivery applications, including one with Elsevier in the Woodhead Publishing in Biomaterials series, and has published many books chapters and journal articles. He has two patents to his name.