Engineering Translational Models of Lung Homeostasis and Disease

ISBN-13: 9783031266249 / Angielski

Chelsea M. Magin

Opis

Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges are highlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science.·         Each section focuses on a specific region of the lung, presenting either the biological or clinical perspective along with complimentary engineering approaches ·         Covers the interface of engineering and lung biology ·         Highlights emerging new models to study lung disease and repair

Spis treści

1. Introduction to the book (Darcy and Chelsea)

Section I: Vasculature

1. Translator: Laura Niklason, Yale University
2. Engineering I: Jordan Miller, Rice University
3. Engineering II: Peter Chan, Wei Tan, University of Colorado at Denver 

Section II: Alveoli

Translator: Jason Spence, University of Michigan

Engineering I: Darcy Wagner, Lund University

1. Engineering II: Olivier Guenat, University of Bern 

Section III: Fibroblasts

1. Translator: Daniel Tschumperlin, Mayo Clinic
2. Engineering I: Janette Burgess, University of Groningen
3. Engineering II: Chelsea Magin, University of Colorado 

Section IV: Airways         

1. Translator: Sam Janes, University College London, Scott Randell, University North Carolina, Martin Birchall, University College London
2. Engineering I: Adam Feinberg, Carnegie Mellon University
3. Engineering II: Don Ingber, Harvard University/Sarah Gilpin, Massachusetts General Hospital

Section V: Engineering the clinical interface between medical materials and the lung

13.   Translator: Sandra Lindstedt (ECMO, EVLP, endobronchial valves, sealants, stents), Lund University

14.   Engineering: Sinem Tas, Lund University

1. Concluding (lymph, nervous/innervation, immune)

O autorze

Dr. Chelsea Magin is an Assistant Professor in the Department of Bioengineering, Department of Pediatrics, and the Division of Pulmonary Sciences and Critical Care Medicine in the Department of Medicine at the University of Colorado, Denver | Anschutz Medical Campus. Dr. Magin leads a laboratory that engineers biomaterials for translational studies of lung disease and repair.

Blurb

Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. 

Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges are highlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science.

Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com