Endotoxin Induced-Shock: A Multidisciplinary Approach in Critical Care

ISBN-13: 9783031185908 / Angielski / Twarda / 2023 / 133 str.

Silvia de Rosa; Gianluca Villa

Opis

This book provides easy consultation and guidance for an appropriate understanding and management of endotoxic shock. Endotoxic shock results from a severe, generalized inflammatory response induced by bloodstream infection with gram-negative bacteria. However, endotoxin-induced inflammatory activation may be disconnected by Gram-Negative threats (e.g. Gram-Positive and yeast infections) as well as occur in multiple clinical scenarios like post-cardiac arrest syndrome and trauma, possibly due to gut barrier dysfunction and consequent endotoxin translocation.The clinical management is structured focusing and dedicating a chapter for antibiotics, corticosteroids, volume support, vasoactive and cardiostimulating drug, coagulopathy and nutritional support. In addition, this book is remarkable because describing polymixin b hemoperfusion points out molecular interactions, and hydrodynamics of Sorption.Each section includes •) brief pathophysiology; •) principles of management; •) key messages. Readers can find updated tips related to the diagnosis and management of endotoxic shock with a multidisciplinary approach drawing a pathway from endotoxin structure and source and the related pathophysiology of endotoxic shock underling the specific clinical aspect and focusing on medical clinical management of endotoxemia and extracorporeal removal.The book – written by international opinion leaders of this field – is addressed to healthcare providers working in intensive care and represents a point of reference for intensivists, infectious disease physicians, nephrologists and critical care nurses involved in the management of endotoxic shock and enriched with useful downloadable material.

Spis treści

Endotoxin: Structure Source and Effects.- Pathophysiology of Endotoxic Shock.- Host Resistance to Endotoxic Shock.- Endotoxin and Organ Cross-talk.- Endotoxin Measurement in Septic Shock.- Clinical Management of Endotoxemia: Antibiotics.- Clinical Management of endotoxemia: volume support.- Clinical Management of Endotoxemia: Corticosteroids.- Clinical Management of Endotoxemia: Vasoactive and Cardiostimulant Drugs.- Clinical Management of Endotoxemia: Source Control.- Clinical Management of Endotoxemia: Treatment of DIC.- Clinical Management of Endotoxemia: Metabolic and Nutritional Support.- Strategies to Reduce Endotoxin Activities.- Extracorporeal Removal of Endotoxin.

O autorze

Silvia De Rosa is Anaesthesiologist and Intensivist at Department of Anaesthesia and Intensive Care, Santa Chiara Regional Hospital, APSS Trento, Italy; Centre for Medical Sciences – CISMed University of Trento, via S. Maria Maddalena, Italy. She is also a clinical researcher in Acute Kidney Injury and  Extracorporeal Organ Support at International Renal Research Institute of Vicenza.  She is a Next Committee Representative of the European Society of Intensive Care Medicine (ESICM) and Regional Councilor of “Italian Society of Anesthesia Analgesia and Intensive Care” (SIAARTI - Veneto Region). Her field of interest are Acute Kidney Injury and Extracorporeal Organ Support, Brain Trauma, Nutrition and Muscle Wasting, Airways Management. Co-investigator of the International registry on Acute Renal Replacement Therapy (Global-ARRT Registry).

Gianluca Villa is Associated Professor in Anaesthesiology, Intensive Care and Pain Medicine at the University of Florence. He is also a clinical researcher in Acute Kidney Injury and Extracorporeal Organ Support at International Renal Research Institute of Vicenza. Principal investigator of the International registry on Acute Renal Replacement Therapy (Global-ARRT Registry).