Endogenous and Exogenous Regulation and Control of Physiological Systems

ISBN-13: 9780849396946 / Angielski / Twarda / 1999 / 464 str.

Robert B. Northrop

Opis

This book stresses an analytic and quantitative approach in describing the basic components of physiological regulators and control systems (PRCs). The author presents a grounding in the classical means of designing linear and nonlinear systems. There is also cutting-edge material on the potential of PRCs to treat immune system ailments, most notably AIDS and cancer. The focus is on certain wet physiological regulators, such as those using endocrine hormones as parametric control substances. The inherent nonlinearity of PRCs is stressed. The author also addresses the problems associated with linear systems that have transport lags. The book describes instances in which exogenous control has been effective, such as the regulation of plasma glucose, mean arterial pressure, and pain. Compartmental analysis is utilized to map the dynamics of drug distribution for more effective results. The author also illustrates the design of closed-loop drug input controllers. Endogenous management is considered in context of the hormonal control of sodium, potassium and calcium ions. The kidneys are key elements in this type of parametic regulation. Also examined is the regulation of plasma gluco

Spis treści

Introduction to Physiological Regulators and Control Systems. Physical and Chemical Factors Governing the Behavior of PRCs. Introduction to Compartmental Modeling and Pharmacokinetic Systems. Special Types of Closed-Loop Drug Input Controllers. Regulation of Blood Glucose. Control of Mean Arterial Pressure by Sodium Nitroprusside Injection. Control of Post-Operative Pain by Self-Administered Opioids. The Human Immune System Seen from a Biomedical Engineering Viewpoint. Some Simulation Packages Suitable for Modeling Nonlinear Systems.


NTI/Sales Copy

O autorze

Robert B. Northrop (University of Connecticut, Storrs, USA) (Author)