1. Overarching concepts in tissue engineering and regenerative medicine 2. Stem cells of various kinds: provenance, classification and useful properties. (ESC, iPSC, tissue specific epithelia, mesenchymal, cord blood, etc.) 3. Stem cell niches in various tissues 4. Harnessing stem cells for tissue regeneration 5. Tissue engineering as a surgical discipline 6. Approaches to tissue engineering: matrix choices, organ decellularization 7. Creating artificial tissue niches for tissue engineering creating stem cell niches, bioreactors 8. Tissue engineering and regenerative medicine approaches and applications in various tissues:Brain, bone and joint, eye, gut, heart, kidney, lung, liver, muscle, pancreas, skin, tendon 9. Regulatory pathways and barriers to implementation of tissue engineering and regenerative medicine 10. The value proposition for tissue engineering and regenerative medicine: how to get the job done