Emerging Modalities in Mitigation of Antimicrobial Resistance

ISBN-13: 9783030841287 / Angielski / Miękka / 2023 / 577 str.

Nadeem Akhtar; Kumar Siddharth Singh;Prerna

Opis

Antimicrobial resistance (AMR) is one of the deadliest threats to global public health. This book focuses on dynamics in the landscape of AMR while informing about the latest technologies and strategies to mitigate it. The menace of AMR in different niches, routes of penetration across various domains, socio-economic impact, and the need for a 'One Health' approach in mitigating AMR has been emphasized. Factors involved in AMR, underlying mechanisms, and pharmacometrics in developing antimicrobials are highlighted. Emphasis is given to emerging technologies that are sustainable, scalable, and applicable to the global community, such as big data analytics, bioactive agents, phage therapy, and nanotechnology. The book also explores current and alternative treatment strategies to combat AMR, emphasizing the use of nanoparticles to target pathogens and as a viable alternative to antibiotics.

Spis treści

​A. Current status and active dynamics of AMR

1. Antimicrobials in livestock production and its cross-domain dynamics

Bishwo Pokharel*, Sandeep Raj Karna

2. Antibiotics and resistance in environment

Rahil Changotra, Atul Chalotra, Himadri Rajput*

3. Antimicrobials in agriculture and its implications in antimicrobial resistance

Shweta Singh and Arun Goyal*

4. Modern diagnostic tools for rapid detection of multidrug resistance

Nimisha Tehri*, Saurabh Kadyan, Tejinder P. Singh, Piyush Tehri, Amit Vashishth

5. The Use of Antimicrobials in Agriculture and socio-economic considerations in global world

Himadri Rajput, Swati Dhiman, Rahil Changotra*

6. Epidemology of microbial infections

Kanika, Aneesh Ali, Md. Meraj Ansari, Rehan Khan*

7. Socioeconomic impact of antimicrobial resistance and their integrated mitigation by One Health approach

Md.Meraj Ansari, Kaushik Kuche, Rohan Ghadi, Tushar Date, Dasharath Chaudhari, Rehan Kha, Sanyog Jain*

B. Mode of action of antimicrobials in mitigation of AMR

8. Regulations in antimicrobial drug development Challenges, and new incentives

Sanjana Kumariya, Richa Mehra, Rashmi Kumariya*

9. New Insights into and updates on antimicrobial agents

Vagish Dwibedi, Santosh Kumar Rath*

10. Polyphenols as emerging antimicrobial agents   

Ashraf Ali, Antonio Parisi, Giovanni Normanno*

11. Antimicrobial peptides and small molecules as antibiotics substitute

Nidhi Sethi*

12. Molecular mechanisms of antimicrobial resistance in S. aureus biofilms

Vanessa Silva, José L. Capelo, Gilberto Igrejas and Patrícia Poeta*

13. Antimicrobial resistance: meaning and developing realization

Atul K. Chandu, Samsher Singh*, Santosh K Rath

14. Chemical diversity in fungi: strategies to mitigate antimicrobial resistance

Neha Kapoor, Richa Bhardawaj and Lokesh Gambhir*

15. Phage therapy as an alternative treatment in the fight against AMR: Real-world problems and possible futures

Rajni Kaur, Nidhi Sethi*

C. Novel strategies to combat AMR

16. Omics and in-silico approaches in the surveillance and monitoring of antimicrobial resistance Ajith M. Thomas, Lija L. Raju, S. Sudheer Khan*

17. Antimicrobial activity of bioactive compounds (Thymoquinone & Eugenol) and its nanoformulations therapeutic potential.

Jasmeet Kaur, Mohamad Taleuzzaman*,  Iqra Rahat

18. Nanoparticles as a future alternative against multiple drug resistance

Md.Meraj Ansari, Kaushik Kuche, Rohan Ghadi, Tushar Date, Dasharath Chaudhari, Faiyaz Ahmad Ansari, Rehan Khan, Akshay Vyawahare, Sanyog Jain*

19. Nano-cargos Boarded Defensins to Combat Multi-drug Resistance

Saurabh Bhorkade, Pawan Kumar Pandey, Md. Meraj Ansari, Sanyog Jain*

20. Implementation of nano-vehicles to disguise and fight multi-drug resistance

Tharun K Bollu, Divya S Parimi, Chandra S Bhatt, Imran Uddin, Anil K Suresh* 

21. Silver nanoparticles as potent multi-drug resistant in-corporants in biomedicine

Imran Uddin, Divya S. Parimi, Tarun K. Bollu, Chandra S. Bhatt and Anil K. Suresh*

22. Role of gold nanoparticles against bacterial multidrug resistance (MDR): An emerging therapeutic revolution

Kaushik Kumar Bharadwaj, Bijuli Rabha, Bhabesh Kumar Choudhury, Aditi Das, Lydia Islary, Dorothy Bhattacharjya, Monoswi Chakraborty, Debabrat Baishya, Arabinda Ghosh* 

23. Carbon nanoparticles: A potential cost-effective approach to counter antimicrobial resistance

Afroza Khanam* and Firdous Ahmad Khan

24. Antimicrobial interfaces as augmentative strategy against antimicrobial resistance

Sunny Dholpuria*, Rohit Kumar, Niraj Kumar Jha, Shipra Jha, Sharad Agrawal

25. Nano- Strategies against rising Antimicrobial resistance (AMR) - Metallic Nanoparticles as Nano-weapon

Purnima Sharmaa, Dinesh Goyal, and Bhupendra Chudasama*

O autorze

Nadeem Akhtar, PhD, Department of Animal Biosciences, University of Guelph, Ontario N1G 2W1, Canada. Email: nadeembiotech@gmail.com. Dr. Nadeem Akhtar, Ph.D., currently works at the University of Guelph, Canada as a Research Associate. His current research focuses on biotechnology in animal nutrition, where the main objective is to improve animals' health for a better and disease-free lifestyle. Before the Research Associate role, he has worked as a Post-doctoral Researcher in the Department of Chemical Engineering, University of Waterloo, Canada (2019-2020), and in the Department of Animal Biosciences, University of Guelph, Canada (2015-2019). Dr. Akhtar was awarded a Ph.D. from the Department of Biotechnology, Thapar University, India. He has qualified National Eligibility test (NET-2010) and Graduate Aptitude Test (GATE) in Life Sciences (2010) and Biotechnology (2011). His scientific contributions include more than 22 articles in peer-reviewed international journals, 10 book chapters, and a patent. He reviewed several research articles for reputed journals, including RSC Advances, Journal of Applied Microbiology, Scientific Reports, Poultry Science, and many more. 

Dr. Kumar Siddharth Singh, Institute for Microbiology, Leibniz University, Hannover, 30419, Germany. Email: ksid21@gmail.com. Dr. Kumar Siddharth Singh is a trained biotechnologist interested in host-microbe interactions, protein science, molecular microbiology, and omics technologies. He has a Master's degree in Biotechnology from Thapar University, Patiala, India, and Bachelor's degree from Anugrah Narayan College, Patna, India. He obtained a Ph.D. in Animal Biotechnology from ICAR-National Dairy Research Institute, Karnal, India, and developed a potential nutraceutical of probiotic origin to protect against gastrointestinal infections. He is also trained in food safety and quality management, emphasizing regulatory standards relevant to the food and biotechnology industry. He has teaching experience at graduate and post-graduate levels and has many years of mentoring experience. He has industry exposure, more than four years of post-doctoral research experience, and has been awarded many national and international academic awards at different levels of his career from different agencies. He has many scientific articles and reviews to his name and serves as an editorial board member of two journals. 

Prerna, Thapar Institute of Engineering and Technology, Patiala, Punjab, India. Email: prerna.biotechnology@gmail.com. Prerna is a Ph.D. Candidate at the Department of Biotechnology, Thapar Institute of Engineering and Technology, India, since July 2013. She received a scholarship under the Government of India scheme TEQIP-II (July 2013- June 2016) and served as a teaching assistant in Biotechnology.  Her current research focuses on developing green novel strategies to fabricate various nanoparticles and interests, including nanobiotechnology in medicine, industry, and agriculture. She has optimized gram-scale synthesis of nanoparticles from various plants and alga. She is involved in evaluating strategies employed to remediate industrial wastes with a vision to conserve soil and water, promote water reuse efficiency, and protect soil and water quality in diverse agro-ecosystems. As a member of the interdisciplinary research group, she used different plants, algae, fungi, and bacteria to fabricate ZnO nanoparticles. She has extensive experience in characterizing nanoparticles using different spectroscopic, diffractographic, crystallographic, and advanced microscopic analyses. She served as a resource person for different training programs and workshops at STEP (Science and Technology Entrepreneur's Park), Thapar Institute of Engineering and Technology. She has published two research articles, two book chapters and presented her research in many conferences and symposia.  

Dinesh Goyal, Thapar Institute of Engineering and Technology, Patiala, Punjab, India. Email: dgoyal@thapar.edu. 

Dinesh Goyal, microbiologist graduated from Division of Microbiology, Indian Agricultural Research Institute, New Delhi in 1990. He served at University of Delhi, New Delhi and Thapar Centre for Industrial Research, Patiala before joining Thapar Institute of Engineering and Technology (Deemed to be University), Patiala as a faculty in 2000 and is presently the Professor in the Department of Biotechnology. He did Post-Doctoral Research at the Department of Bioengineering, Tokyo Institute of Technology, Tokyo, Japan during 1993 to 1995 and later underwent two weeks training on Technology Entrepreneurship and Education at Walter A Haas Business School, University of California, Berkeley, online training on Marketing for Incubator managers and entrepreneurs organized by Asia Pacific Incubator's Network (APIN) and accomplished many orientation courses on higher education, human values, IPR and commercialization of technology and innovation.

His current interests are in applied microbiology and biotechnology and is focusing on nano-bioremediation and nano-antimicrobials. He has published more than 100 articles, two patents, 14 book chapters, compiled three manuals and guided the research work of 19 Ph.D students, 10 project fellows, B.Tech, 60 M.Sc., and 08 M.Tech. students.  

He has organized more than thirty-five training programs and workshops in microbiology, biotechnology and entrepreneurship and eight national and one international conference. He was nominated four times (2006-08) as an expert member of National Board of Accreditation (NBA) by All India Council for Technical Education (AICTE) for evaluation and accreditation of B.Tech Biotechnology program. He is also the recipient of prestigious Japanese Govt (Mombusho) Scholarship (1993-95), Fellow of International Congress of Chemistry and Environment (2009), Fellow of Association of Biotechnology and Pharmacy (2010), and Shiksha Rattan Puraskar (2011), Fellow of Association of Microbiologists of India (2012) and Fellow of Institute of Water and Environment (2014). 

Blurb

This book provides an overview of cutting-edge and next-generation research and technologies for combating antimicrobial resistance. Antibiotic-resistant infections are projected to cause 10 million deaths annually by the year 2050. A sustainable, unified approach by researchers, practitioners, policymakers, and the public is urgently needed to stem this trend. This book aims to provide a comprehensive summary of current and future-facing efforts to mitigate the threat of AMR through a One-Health approach. This book is a valuable resource for students, researchers, policymakers, and the public about AMR and novel strategies to combat AMR.