Egf Receptor in Tumor Growth and Progression

ISBN-13: 9783662033937 / Angielski / Miękka / 2014 / 258 str.

R. B. Lichtner; R. N. Harkins

Opis

The tyrosine kinases are frequently implicated in experimental as well as in human cancer. The best-studied receptor signaling system from this family is the EGF receptor. Experts in this area report on the involvement of the receptor in a variety of human tumors, outline underlying molecular mechanisms for aberrant receptor signaling in experimental systems and present the status of current therapies. A detailed analysis of EGF receptor signal transduction via expression of receptor, ligands, phosphatases and presence of other members of the receptor family will provide new information for the design of therapeutic modalities targeting this receptor system.

Spis treści

1 Signal Transduction by EGF Receptor Tyrosine Kinase.- 2 Characterization of Growth Factor Receptor-Directed Protein Tyrosine Phosphatases.- 3 Interaction of Heparin-Binding EGF-Like Growth Factor with Multiple Receptors.- 4 Epidermal Growth Factor Receptor Expression in Head and Neck Tumorigenesis and Saturation of EGFR with Monoclonal Antibody RG83852.- 5 EGF Receptors as a Target for Therapy and Interactions with Angiogenesis.- 6 erbB Signalling and Endocrine Sensitivity of Human Breast Cancer.- 7 The Role of Estrogen in the Regulation of EGFR Expression.- 8 Multifunctional Growth Factors in Tumor Progression.- 9 The Role of Epidermal Growth Factor Receptor in the Initiation and Progression of Malignancy.- 10 Preclinical Studies with Human Tumour Xenografts Using Rat Monoclonal Antibodies Directed Against the Epidermal Growth Factor Receptor.- 11 Recombinant Fusion Toxins Targeted to Members of the ErbB Family of Receptor Tyrosine Kinases.- 12 EGF Receptor Inhibition by Antibody as Anticancer Therapy.- Previous Volumes Published in this Series.

Blurb

Members of the tyrosine kinase family are frequently implicated in experimental as well as in human cancer. The best studied receptor signaling system from this family is the EGF receptor. Experts in this area report on the involvement of the receptor in a variety of human tumors, outline underlying molecular mechanisms for aberrant receptor signaling in experimental systems and present the status of current therapies directed against the receptor. A detailed analysis of EGF receptor signal transduction via expression of receptor, ligands, phosphatases and presence of other members of the receptor family will provide new information for the design of therapeutic modalities targeting this receptor system.