Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part I: Volume 160

ISBN-13: 9780128208052 / Angielski / Twarda / 2021

Shafiqur Rahman; Richard L. Bell

Spis treści

Preface: Introduction to Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS. R. L. Bell & S. Rahman 1. The Persistent Impact of Adolescent Binge Alcohol on Adult Brain Structural, Cellular, and Behavioral Pathology: a Role for the Neuroimmune System and Epigenetics. Leon G Coleman Jr, Fulton T Crews, & Ryan P. Vetreno 2. Neuroepigenetic Consequences of Adolescent Ethanol Exposure E. Brocato & J. T.T. Wolstenholme 3. Trajectories of Brain Development Revealing Times of Risk and Factors Promoting Resilience to Alcohol use in Adolescence. S. Lannoy & E.V. Sullivan 4. Chronic Alcohol Exposure during Critical Developmental Periods Differentially Impacts Persistence of Deficits in Cognitive Flexibility and Related Circuitry. C. A. Dannenhoffer, M. M. Robertson, V. A. Macht, S. M. Mooney, C. A. Boettiger, & D. L. Robinson^, 5. Effects of Adolescent Substance Use Disorders on Central Cholinergic Function. S.R. Hauser, Z.A. Rodd, G.A. Deehan, Jr, T. Liang, S. Rahman, R.L. Bell 6. Regulation of Glutamate Signaling in the Extended Amygdala by Adolescent Alcohol. E.B. Holmgren, T.A. Wills 7. The Effects of Peri-Adolescent Alcohol Use on the Developing Hippocampus C.D. Walker, C.M. Kuhn, M-L.Risher 8. Consequences of Adolescent Alcohol Use on Adult Hippocampal Neurogenesis and Hippocampal Iintegrity. J.I. Wooden, K. R. Thompson, S.P. Guerin, N. N. Nawarawong, K. Nixon 9. The Role of Sex in the Persistent Effects of Adolescent Alcohol Exposure on Behavior and Neurobiology in Rodents. D. L. Robinson & colleagues  10. Future Directions for Part I: Substance Use Disorder in Adolescence-A Vision for a Better Future S. Rahman & R. L. Bell

O autorze

Shafiqur Rahman, Ph.D. is Professor of Pharmacology in the Department of Pharmaceutical Sciences at South Dakota State University (SDSU) in Brookings, USA. He received his Ph.D. in Neuropharmacology from the Memorial University of Newfoundland, Canada. Dr. Rahman completed his post-doctoral fellowship in the Department of Psychiatry from Indiana University School of Medicine in Indianapolis in USA. Prior to joining SDSU, he worked as research scientist and faculty at the University of Kentucky in Lexington, USA and the University of Toronto, Canada. Dr. Rahman's research focus is drug discovery in neuropharmacology, i.e. the development of novel therapeutic candidates for the treatment of drug addiction and neuropsychiatric disorders. His research and scholarship has resulted in over 125 publications and 11 edited books/book chapters. Dr. Rahman served as editor, editorial board member and reviewer for numerous Scientific Journals and review panels related to drug addiction, neuropharmacology, and drug discovery research. Dr. Rahman is also a member of several professional societies or organizations, including Society for Neuroscience, American Society for Experimental Neurotherapeutics, and American Society for Pharmacology and Experimental Therapeutics. Dr. Bell received a Bachelor of Arts in General Psychology and Addiction Counseling from Minot State University (Minot, ND) and went on to receive a Master of Science and a Doctor of Philosophy in Applied Biopsychology, with a minor in Biostatistics, from the University of New Orleans (New Orleans, LA). He is presently an Associate Professor of Psychiatry at the Indiana University School of Medicine (Indianapolis, IN). He has been researching the in vivo effects of alcohol for 20 years and has maintained continuous funding from the National Institutes of Health-National Institute on Alcohol Abuse and Alcoholism for close to 15 years. His research during this time has focused on the behavioral genetics of rat lines selectively bred to consume high, vs very low, amounts of ethanol. The high ethanol-consuming rat lines display intakes corresponding with that of a 70 kg male drinking a fifth, or more, of 90-proof whiskey every day. These rat lines display many of the behavioral, physiological, neurochemical and genetic characteristics observed in clinical family history positive (FHP), for alcoholism, individuals; whereas the low ethanol-consuming rat lines serve as an animal model of family history negative (FHN) individuals. Moreover, these high ethanol-consuming rat lines meet established criteria for an animal model of alcoholism. Regarding this, he has written extensively on the genotypic as well as behavioral and neurochemical phenotypic characteristics of these and other major, international selectively bred high vs low ethanol-consuming rat lines. His more recent research has focused on three major areas: (1) innate and ethanol-induced changes in gene expression within subregions of the mesocorticolimbic and extended amygdala reward neurocircuits; (2) the acute as well as chronic behavioral and neurochemical effects of ethanol and/or nicotine exposure during adolescence and emerging adulthood; and (3) differences in the genetic, behavioral and neurochemical effects of binge-like, non-binge-like and relapse-like ethanol drinking and/or nicotine consumption. Scholastically, Dr. Bell has presented his findings to professional and lay audiences locally, nationally and internationally. He has published approximately 120 journal articles and book chapters. He serves as Associate Editor, Review Editor or Reviewer for over 50 international journals. He serves as a grant reviewer for the Veterans Affairs and the National Institutes of Health as well as multiple international academic institutions and is a member of the Research Society on Alcoholism-Animal Research and Ethics Committee.