Effects of Fluoroquinolones on the Helicase Activity of HCV

ISBN-13: 9783659936005 / Angielski / Miękka / 2016 / 160 str.

Irfan Khan

Opis

HCV has infected 170 million individuals worldwide. Effective therapy against HCV is still lacking and there is a need to develop potent drugs against the virus. In the present study, we have employed two culture models to test the activity of fluoroquinolone drugs against HCV: a subgenomic replicon that is able to replicate independently in the cell line Huh-8 and the Huh-7 cell culture model that employs cells transfected with synthetic HCV RNA to produce the infectious HCV particles. Fluoroquinolones have also been shown to have inhibitory activity against certain viruses, possibly by targeting the viral helicase.

O autorze

I am a Research Scientist in the Department of Chemistry and the RNA Institute at the State University of New York at Albany. I am currently innovating activatable nanoprobes for targeted delivery of anticancer agents, Knock down of certain oncogenes in Breast cancer cells and siRNA mediated activation of chemotherapeutic drugs.