Effect of generation G on cancer targeting propensity of PPI dendrimer

ISBN-13: 9783844392852 / Angielski / Miękka / 2015 / 208 str.

Prashant Kesharwani

Opis

This book discussed the single platform assessment of targeting potential of anticancer drug loaded plain as well as folate anchored PPI dendrimer of different generations. This is the debut study to explore the effect of generation on the drug delivery aspects of plain and folate-conjugated PPI dendrimer. Folic acid used as a model targeting ligand due to its promising acceptability in cancer targeting. The folate conjugation is also expected to enhance biocompatibility of cationic dendrimer due to shielding of peripheral cationic groups. It is anticipated that the the developed dendrimer-based nano-formulation will generate a safe, effective and stable formulation that will help in successful transformation of dendritic formulations from laboratory to clinical stages.

O autorze

Dr. Prashant Kesharwani grew up in Sagar, India. In 2014, he obtained his PhD degree from Dr H. S. Gour University, Sagar. Dr. Kesharwani currently works as a Post-Doc Fellow in Wayne State University,USA. An overarching goal of his current research is development of nano drug deliver systems. He co-authored more than 25 international publications.