Effect of CoCl2 in vascular dysfunction of diabetic nephropathy

ISBN-13: 9786139927982 / Angielski

Aaishwarya Deshmukh; Jayvadan Patel

Opis

A variety of human disorders are characterized by, or associated with, tissue hypoxia and manipulation of the HIF pathway has been predicted to significantly alter their clinical course. Early hopes of developing revolutionary PHD-based therapies have yet to translate into novel licensed pharmaceutical agents. Diabetic nephropathy, a progressive development of renal insufficiency in the setting of hyperglycaemia is the major single cause of chronic renal failure (CRF) in which hypoxia plays a critical role. The study investigated the efficacy of cobalt chloride (CoCl2), a Prolyl 4-hydroxylase (PHD) inhibitor in amelioration of renal injury, endothelial dysfunction as well as its effect on hyperglycemia in uninephrectomized diabetic rat. The study signifies the effect of CoCl2 in amelioration of renal failure and associated vascular dysfunctuion.

O autorze

Deshmukh, Aaishwarya
Dr. Aaishwarya B. Deshmukh is having experience of 11+ years in pharmaceutical R&D and Academics. She has also served as executive scientist at Torrent research centre, Project coordinator at Dishman Pharmaceuticals ltd and has 20 research publications and 05 book chapters. She has presented papers in many national and international conferences.