Effect-Directed Analysis of Complex Environmental Contamination

ISBN-13: 9783642183836 / Angielski / Twarda / 2011 / 364 str.

Werner Brack

Opis

Today more than 5 million chemicals are known and roughly 100,000 of them are frequently used, with both numbers rising. Many of these chemicals are ultimately released into the environment and may cause adverse effects to ecosystems and human health. Effect-directed analysis (EDA) is a promising tool for identifying predominant toxicants in complex, mostly environmental mixtures combining effect testing, fractionation and chemical analysis. In the present book leading experts in the field provide an overview of relevant approaches and tools used in EDA. This includes diagnostic biological tools, separation techniques and advanced analytical and computer tools for toxicant identification and structure elucidation. Examples of the successful application of EDA are discussed such as the identification of mutagens in airborne particles and sediments, of endocrine disruptors in aquatic ecosystems and of major toxicants in pulp and paper mill effluents. This book is a valuable, comprehensive and interdisciplinary source of information for environmental scientists and environmental agencies dealing with the analysis, monitoring and assessment of environmental contamination.

Spis treści

Early Evolution of the Toxicity Identification Evaluation Process: Contributions from the United States Environmental Protection Agency Effluent Testing Program
Gerald T. Ankley, James R. Hockett, Donald I. Mount, David R. Mount

Recent Developments in Whole Sediment Toxicity Identification Evaluations (TIEs): Innovations in Manipulations and Endpoints
Robert M Burgess, Kay T Ho, Adam D Biales, Werner Brack

Considerations for Incorporating Bioavailability in Effect-Directed Analysis and Toxicity Identification Evaluation
Werner Brack, Robert M Burgess

Diagnostic tools for Effect-Directed Analysis of mutagens, AhR agonists and endocrine disruptors
Gisela Umbuzeiro, Miroslav Machala, Jana Weiss

Separation Techniques in Effect-Directed Analysis
Werner Brack, Nadin Ulrich, Mahmoud Bataineh

Simultaneous screening and chemical characterization of bioactive compounds using LC-MS based technologies (affinity chromatography)
Martin Giera and Hubertus Irth

Advanced GC-MS and LC-MS tools for structure elucidation in effect-directed analysis
Pim Leonards, Rikke Brix, Damià Barceló, and Marja Lamoree

Computer Tools for Structure Elucidation in Effect-Directed Analysis
Emma Schymanski, Tobias Schulze, Jos Hermans and Werner Brack

Effect-directed analysis of mutagens in ambient airborne particles
John L. Durant and Arthur L. Lafleur

Effect-Directed Analysis of endocrine disruptors in aquatic ecosystems
Corine J. Houtman, Juliette Legler, Kevin Thomas

Effects-directed studies of pulp and paper mill effluents
Mark Hewitt

Effect-directed analysis of Ah-receptor mediated toxicants, mutagens and endocrine disruptors in sediments and biota
Markus Hecker and John P. Giesy

Ecological relevance of key toxicants in aquatic systems
Mechthild Schmitt-Jansen, Peter von der Ohe, Stephanie Franz, Stefanie Rotter, Sergi Sabater, Dick de Zwart, Helmut Segner

O autorze

Dr. Werner Brack war Geschäftsführer eines großen Softwarehauses. Sein lebenslanges Interesse an der Seefahrt fand u.a. in einer umfangreichen Bildsammlung seinen Ausdruck.