Early Vascular Aging (EVA): New Directions in Cardiovascular Protection

ISBN-13: 9780443155123 / Twarda / 2024 / 550 str.

Spis treści

SECTION 1 - Introduction
1. Historical Aspects and Biology of Aging
2. The 5 paradigm shifts in cardiovascular aging research
3. Vascular Aging and Cardiovascular Disease

SECTION 2 - Lifecourse Approach and Population based Studies
4. Aging Population: Challenges and Opportunities in a Life Course
5. Population-Based Studies: Milestones on the Epidemiological Timeline
6. Lessons from the Amsterdam Growth and Health Longitudinal Study
7. Cardiovascular Aging: Perspectives from Longitudinal Studies of Aging
8. Lessons from the Cardiovascular Risk in Young Finns Study
9. Early Vascular Aging in the Young
10. Vascular Aging and Ethnicity

SECTION 3 - Molecular, Cellular and Mechanist Contributions to Vascular Aging
11. Cellular and Molecular Determinants of Arterial Aging
12. Early Aging of Endothelial Function and Platelet/Vessel Wall Interactions
13. Age-Induced Endothelial Dysfunction and Intima-Media Thickening
14. Glucose Metabolism, Diabetes, and the Arterial Wall
15. The Cross-Talk Between the Macro- and the Microcirculation
16. Changes in Peripheral Blood Pressure with Normal and Accelerated Aging
17. Changes in Arterial Stiffness with Normal and Accelerated Aging
18. Changes in Central Hemodynamics, Wave Reflection, and Heart-Vessel Coupling with Normal and 19. Arterial Stiffness and Blood Pressure Variability
20. Chronic Inflammation and Arterio/Atherosclerosis
21. Non-Hemodynamic Components of EVA: Polycystic Ovary Syndrome (PCOS)
22. Microbiota, Diet, Oral Health and Vascular Aging

SECTION 4 - Biomarkers, risk prediction and phenotypes of vascular aging
23. Traditional Versus New Models of Risk Prediction
24. Estimated vs measured arterial stiffness
25. Vascular Aging Biomarkers: Methodological Measurement Consensus and Reference values
26. Imaging Biomarkers: Carotid Intima-Media Thickness and Aortic Stiffness as Predictors of Cardiovascular Disease
27. Imaging Biomarkers: Flow Mediated Dilation as Predictor of Cardiovascular Disease
28. Genetic Markers in Prediction of Cardiovascular Disease
29. Phenotypes of Vascular Aging - Vascular Chronobiologic asynchrony

SECTION 5 - Vascular Aging, Organ Damage and Late Stage Disease
30. Early and Late Stages of Chronic Kidney Disease in Relation to Arterial Changes
31. Arterial Aging, Blood Pressure and Brain Damage
32. Clinical implications of ventricular-arterial coupling and the role of therapeutic interventions
33. Ventricular-Arterial Coupling and Heart Disease

SECTION 6 - Translating Research into clinical practice, with precision cardiovascular medicine
34. Vascular Aging and Clinical Trials
35. PART I Treatment of Abnormalities in Lipid Metabolism and EVA
36. PART II Early Vascular Aging and Obesity Treatment
37. PART III Treatment with anti-diabetes drugs - Effects on blood pressure and central hemodynamics
38. PART IV Arterial Stiffness as a Treatment Target
39. Lifestyle Intervention: What Works?
40. Targeting Blood Pressure Lowering and the Sympathetic Nervous System
41. Targeting Central Blood Pressure Through the Macro- and Microcirculation Cross-Talk
42. Cardiovascular Prevention Strategies in a lifetime perspective
43. Cardiovascular Prevention Strategies in patients with comorbidities (metabolic, chronic inflammation, immunomodulation, cancer and treatment induced arterial changes)
44. Cardiovascular risk prediction
45. Target Organ Damage
46. Therapeutic implications
47. New Drugs Under Development for Cardiovascular Prevention
48. Specific Pathways to prevent Early Vascular Aging
49. Immunization, Vaccines, and Immunomodulation

SECTION 7 - Global Mapping of Vascular Aging Research
50. EUROPE
51. ASIA AND AUSTRALIA
52. NORTH AMERICA
53. SOUTH AMERICA
54. VascAgeNet