SECTION 1 - Introduction 1. Historical Aspects and Biology of Aging 2. The 5 paradigm shifts in cardiovascular aging research 3. Vascular Aging and Cardiovascular Disease
SECTION 2 - Lifecourse Approach and Population based Studies 4. Aging Population: Challenges and Opportunities in a Life Course 5. Population-Based Studies: Milestones on the Epidemiological Timeline 6. Lessons from the Amsterdam Growth and Health Longitudinal Study 7. Cardiovascular Aging: Perspectives from Longitudinal Studies of Aging 8. Lessons from the Cardiovascular Risk in Young Finns Study 9. Early Vascular Aging in the Young 10. Vascular Aging and Ethnicity
SECTION 3 - Molecular, Cellular and Mechanist Contributions to Vascular Aging 11. Cellular and Molecular Determinants of Arterial Aging 12. Early Aging of Endothelial Function and Platelet/Vessel Wall Interactions 13. Age-Induced Endothelial Dysfunction and Intima-Media Thickening 14. Glucose Metabolism, Diabetes, and the Arterial Wall 15. The Cross-Talk Between the Macro- and the Microcirculation 16. Changes in Peripheral Blood Pressure with Normal and Accelerated Aging 17. Changes in Arterial Stiffness with Normal and Accelerated Aging 18. Changes in Central Hemodynamics, Wave Reflection, and Heart-Vessel Coupling with Normal and 19. Arterial Stiffness and Blood Pressure Variability 20. Chronic Inflammation and Arterio/Atherosclerosis 21. Non-Hemodynamic Components of EVA: Polycystic Ovary Syndrome (PCOS) 22. Microbiota, Diet, Oral Health and Vascular Aging
SECTION 4 - Biomarkers, risk prediction and phenotypes of vascular aging 23. Traditional Versus New Models of Risk Prediction 24. Estimated vs measured arterial stiffness 25. Vascular Aging Biomarkers: Methodological Measurement Consensus and Reference values 26. Imaging Biomarkers: Carotid Intima-Media Thickness and Aortic Stiffness as Predictors of Cardiovascular Disease 27. Imaging Biomarkers: Flow Mediated Dilation as Predictor of Cardiovascular Disease 28. Genetic Markers in Prediction of Cardiovascular Disease 29. Phenotypes of Vascular Aging - Vascular Chronobiologic asynchrony
SECTION 5 - Vascular Aging, Organ Damage and Late Stage Disease 30. Early and Late Stages of Chronic Kidney Disease in Relation to Arterial Changes 31. Arterial Aging, Blood Pressure and Brain Damage 32. Clinical implications of ventricular-arterial coupling and the role of therapeutic interventions 33. Ventricular-Arterial Coupling and Heart Disease
SECTION 6 - Translating Research into clinical practice, with precision cardiovascular medicine 34. Vascular Aging and Clinical Trials 35. PART I Treatment of Abnormalities in Lipid Metabolism and EVA 36. PART II Early Vascular Aging and Obesity Treatment 37. PART III Treatment with anti-diabetes drugs - Effects on blood pressure and central hemodynamics 38. PART IV Arterial Stiffness as a Treatment Target 39. Lifestyle Intervention: What Works? 40. Targeting Blood Pressure Lowering and the Sympathetic Nervous System 41. Targeting Central Blood Pressure Through the Macro- and Microcirculation Cross-Talk 42. Cardiovascular Prevention Strategies in a lifetime perspective 43. Cardiovascular Prevention Strategies in patients with comorbidities (metabolic, chronic inflammation, immunomodulation, cancer and treatment induced arterial changes) 44. Cardiovascular risk prediction 45. Target Organ Damage 46. Therapeutic implications 47. New Drugs Under Development for Cardiovascular Prevention 48. Specific Pathways to prevent Early Vascular Aging 49. Immunization, Vaccines, and Immunomodulation
SECTION 7 - Global Mapping of Vascular Aging Research 50. EUROPE 51. ASIA AND AUSTRALIA 52. NORTH AMERICA 53. SOUTH AMERICA 54. VascAgeNet