EFFECT OF EMPAGLIFLOZIN AND METFORMIN IN DIABETIC RATS

ISBN-13: 9786139464388 / Angielski / Miękka / 112 str.

Jagdish Kakadiya; Anteneh Tamirat

Opis

The objective of the present study was to evaluate cardio-protective effect of sodium glucose co-transporter-2 inhibitor alone and its combination with metformin in experimentally induced myocardial infarction in diabetic rats. Group I served as normal control and received vehicle (0.5% hydroxy ethyl cellulose) for 4 weeks and normal saline subcutaneously on 29th and 30th days. Group II served as diabetic-myocardial control and received STZ-NIC (65-120mg/kg, i.p) and Isoproterenol (85mg/kg, sc) on 29th and 30th days. Group III received STZ-NIC, ISO and Empagliflozin 5mg/kg. Group IV received STZ-NIC, ISO and Empagliflozin 10mg/kg. Group V received STZ-NIC, ISO and Empagliflozin 5mg/kg + Metformin 50mg/kg. Animals treated with the combination of Empagliflozin and Metformin showed significant inhibition in the elevated level of BG, CK-MB, LDH, AST, Troponin and lipid profile in diabetic animals compared to diabetic control (Group II) animals and Group III and IV animals receiving only Empagliflozin 5 mg/kg and 10 mg/kg respectively.

O autorze

Kakadiya, JagdishDr. Jagdish L. Kakadiya is an Academician and researcher in the domain of Pharmacy field more than 12 years. He has published more than 25 research and review papers in national & international journals. He has also presented several papers in national & international conferences. He has 10 h-index and 10 i10 Index in Google Scholar.