Drug Repositioning: Approaches and Applications for Neurotherapeutics

ISBN-13: 9780367869076 / Angielski / Miękka / 2019 / 313 str.

Joel Dudley; Laura Berliocchi

Opis

Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases.

Spis treści

Section I The Rationale and Economics

of Drug Repositioning

Chapter 1 Scientific and Commercial Value of Drug Repurposing

David Cavalla

Chapter 2 Repurposing for Alzheimer’s and Parkinson’s Diseases: The

Ideas, the Pipeline, the Successes, and the Disappointments

Hermann Mucke

Chapter 3 Contribution of Not-for-Profit Organizations to Drug Repurposing

Bruce Bloom

Section II Repositioning Approaches and

Technologies: From Serendipity to

Systematic and Rational Strategies

Chapter 4 Systematic Drug Repositioning

Spyros N. Deftereos, Aris Persidis, Andreas Persidis,

Eftychia Lekka, Christos Andronis, and Vassilis Virvillis

Chapter 5 Technical Tools for Computational Drug Repositioning

Francesco Napolitano

Chapter 6 RNAi Screening toward Therapeutic Drug Repurposing

Nichole Orr-Burks, Byoung-Shik Shim, Olivia Perwitasari,

and Ralph A. Tripp

Chapter 7 Phenotypic Screening

Christine M. Macolino-Kane, John R. Ciallella,

Christopher A. Lipinski, and Andrew G. Reaume

Section III Drug Repositioning for

Nervous System Diseases

Chapter 8 A Case Study: Chlorpromazine

Francisco López-Munoz, Cecilio Álamo,

and Silvia E. García-Ramos

Chapter 9 Drug Repurposing for Central Nervous System Disorders: A

Pillar of New Drug Discovery

Mondher Toumi, Aleksandra Caban, Anna Kapuśniak,

Szymon Jarosławski, and Cecile Rémuzat

Chapter 10 Repurposing Opportunities for Parkinson’s Disease Therapies

Giulia Ambrosi, Silvia Cerri, and Fabio Blandini

Chapter 11 Drug Candidates for Repositioning in Alzheimer’s Disease

Maria P. del Castillo-Frias and Andrew J. Doig

O autorze

Dr. Joel Dudley is associate professor of genetics and genomic sciences and director of biomedical informatics at Mount Sinai School of Medicine, New York (NY, USA).

Dr. Laura Berliocchi is associate professor of pharmacology at the Department of Health Sciences, Magna Graecia University (Catanzaro, Italy).