Drug Metabolism in Diseases

ISBN-13: 9780128029497 / Angielski / Twarda / 2016 / 294 str.

Wen Xie

Opis

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology.

• Written and edited by leaders in drug metabolism from academia and industry
• Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more
• Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Spis treści

1. Introduction of Drug Metabolism and Overview of Disease Effect on Drug Metabolism 2. Regulation of Drug-Metabolizing Enzymes and Drug Metabolism by Inflammatory Responses 3. Regulation of Drug Transporters by Inflammation 4. Drug Metabolism in Kidney Disease 5. Drug and Fatty Acid Cytochrome P450 Metabolism in Critical Care 6. Drug Metabolism in Cardiovascular Disease 7. Pharmacogenetic Factors That Affect Drug Metabolism and Efficacy in Type 2 Diabetes Mellitus 8. Hepatic Drug Metabolism in Pediatric Patients 9. Drug Metabolism in Pregnancy 10. Estrogen-Metabolizing Enzymes in Systemic and Local Liver Injuries: A Case Study of Disease-Drug Interaction 11. Xenobiotic Receptors in the Crosstalk Between Drug Metabolism and Energy Metabolism

O autorze

Professor of Pharmaceutical Sciences and Pharmacology, The Joseph Koslow Endowed Chair in Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Director of the Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA