Drug Metabolism: Chemical and Enzymatic Aspects

ISBN-13: 9781420061031 / Angielski / Miękka / 2007 / 200 str.

Jack P. Uetrecht; William Trager

Opis

< P> In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This comprehensive textbook will aid in guiding students through the recognition of the chemical underpinnings of drug metabolism. While there are numerous resources available for understanding drug structure, and other texts relating to drug metabolism from a biological standpoint, there is no other resource currently available that links both the chemical and biological terminology together in a clear and concise language, written, to be accessible for use in the classroom, as an education tool for teaching drug development. Drug Metabolism: Chemical and Enzymatic Aspects explains, to teachers and students alike, how a drug is metabolized, the potential effects of the metabolites, extensive material to help understand drugmetabolism within a biological context, and practical problems and answers.< /P>

Spis treści

Background for Non-Chemists. Background for Chemists. Oxidation Pathways and the Enzymes That Mediate Them. Reductive Pathways. Hydolytic Pathways. Conjugation Pathways. Reactive Metabolites. Practice Problems/Practice Answers

O autorze

Jack P. Uetrecht, William Trager