1 Introduction 2 Historical Perspective 3 Applicability 4 Classification Systems 5 Indications and Contraindications 6 Preparation for DISE: Informed Consent 7 Organization and Logistics 8 Patient Preparation and Positioning 9 Drugs for DISE 10 An Anesthesiological Point of View 11 Work in Progress: A Prediction Model for DISE as Selection Tool for MAD and Positional Therapy 12 Complications of DISE 13 DISE and Treatment Outcomes 14 DISE and Position-Dependent OSA 15 Significance of Complete Concentric Collapse of the Palate 16 Epiglottic Collapse 17 Common Mistakes in DISE 18 Diagnostic and Therapeutic Applications or a Guide for Clinical Practice 19 DISE and Treatment with Mandibular Advancement Devices in Obstructive Sleep Apnea Patients 20 The Use of DISE to Determine Candidates for Upper Airway Stimulation 21 Pediatric Sleep Endoscopy 22 DISE in Children with Craniofacial Anomalies 23 Advanced Technique 24 Future Perspectives