Drug Discovery with Privileged Building Blocks: Tactics in Medicinal Chemistry

ISBN-13: 9781032041735 / Angielski / Twarda / 2021 / 306 str.

Jie Jack Li; Minmin Yang

Opis

Drug Discovery with Privileged Building Blocks traces back PharmaBlockʹs founding philosophy of designing privileged building blocks. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists and veteran medicinal chemists find it useful as well.

Spis treści

Preface 1. Alkynes; 2. Azaindoles; 3. Azetidines; 4. Bicyclic Pyridines Containing Ring-junction N; 5. Bicyclo (1.1.1)pentyl (BCP) as an sp3 Carbon-rich Bioisostere for para-Phenyl and tert-Butyl Groups; 6. Bicyclo[2.2.2]octane (BCO) as A 3D-rich Bioisotere for the para-Phenyl Group; 7. Bicyclo[3.1.0]hexanes; 8. Bridge-Fused Rings as m-Phenyl Bioisosteres; 9. Cubanes, Are We There Yet?; 10. Cyclobutanes; 11. Cyclohexanes; 12. Cyclopentanes; 13. Cyclopropanes as Metabolically More Robust Bioisoteres for Linear Alkyl Substituents; 14. Deazapurines; 15. Furopyridines; 16. Indazoles; 17. Indoles; 18. Oxetanes; 19. Piperidine, the Enchanted Ring; 20. Pyrazines; 21. Pyrazoles; 22. Pyridazines; 23. Pyridines - The Magic of Phenyl-Pyridyl Switch; 24. Pyrimidines; 25. Pyrrolidines; 26. Pyrrolotriazines; 27. Spiroazetidines; 28. Spirocyclic Piperidines; 29. Spirocyclic pyrrolidines; 30. Spirooxetanes; 31. Tetrahydropyrans; 32. Trifluoromethylpyridines. Index