Drug Discovery and Development: From Targets and Molecules to Medicines

ISBN-13: 9789811555336 / Angielski / Twarda / 2021 / 522 str.

Poduri, Ramarao

Opis

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing.Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Spis treści

Chapter 1: Historical Perspective of Drug Discovery and Development

Chapter2: Natural Products and Drug Discovery

Chapter 3: The Concept Of Receptors And Molecules Interaction In Drug  Discovery And Development

Chapter 4: Chemical Structure and Stereochemistry 

Chapter 5:Biased Agonism:Renewing GPCR's targetability

Chapter 6: Computer Aided Drug Discovery

Chapter 7: Pharmacological screening of novel chemical entities

Chapter 8:Drug Target Identification and Validation:

Chapter 9: Genetics and Drug Discovery

Chapter 10: Stem Cells and Therapeutics 

Chapter 11: Pharmacokinetics 

Chapter 12: Regulatory Toxicological Testing

Chapter 13: Nanotoxicology and Regulatory Requirements

Chapter 14: Clinical Trials in Industrial Drug Development

Chapter 15:Pharmacovigilance

Chapter 16: Regulatory Process for New Drug Approval in India

Chapter 17: Pharma Industry, Academia, Regulatory Authorities, and End-user Interaction in the 

Chapter 18: Statistics

O autorze

Dr. Ramarao Poduri, M Pharm, PhD, is currently working as Dean of Academic Affairs, Dean of the School of Basic and Applied Sciences, and a Professor at the Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India. Dr. Poduri graduated from the Banaras Hindu University of India and completed his postdoctoral research at the University of Illinois, Chicago and Harvard Medical School, Boston. With more than 40 years of teaching experience, he has worked at various prestigious institutes, including Banaras Hindu University, NIPER, S.A.S. Nagar and the Central University of Punjab. Dr. Poduri has published more than 140 peer-reviewed research papers and received e.g. the ISCB Award for Excellence (2009), Indian Society of Chemists & Biologists Pharma-Bio Award (2009), and IASTAM Dr. K.M. Parikh Award (2018).