Drug Delivery to the Central Nervous System

ISBN-13: 9781493961597 / Angielski / Miękka / 2016 / 321 str.

Kewal K. Jain

Opis

This book presents essential methods used to deliver therapeutics across the blood brain barrier, both in experimental animals and in humans. It includes detailed protocols as well as several overviews of innovative methods and their applications.

Spis treści

1. An Overview of Drug Delivery to the CNS Kewal K. Jain 2. Receptor-Mediated Transport of Drugs Across the BBB Ji-Ming Feng, Philip C.W. Lui, and Jian Yi Li 3. Disruption of Blood-Brain Barrier by Focused Ultrasound for Targeted Drug Delivery to the Brain Natalia Vykhodtseva 4. Prediction of Blood-Brain Barrier Penetration by Drugs Kiril Lanevskij, Pranas Japertas, Remigijus Didziapetris, and Alanas Petrauskas 5. Intraparenchymal Delivery and Its Discontents Raghu Raghavan 6. Intrathecal Drug Delivery By Implanted Pumps Shawn Belverud, Alon Mogilner, and Michael Schulder 7. Intracarotid Drug Delivery: Revisiting The Past or Looking Into The Future Shailendra Joshi 8. Vesicular Systems for Intranasal Drug Delivery Ibrahim A. Alsarra, Amel Y. Hamed, Fars K. Alanazi, and Gamal M. El Maghraby 9. Convection-Enhanced Drug Delivery and Monitoring in a Rat Model Yael Mardor and Zvi Ram 10. Intrathecal Delivery of Stem Cells to the Spinal Cord Birgit Neuhuber and Itzhak Fischer 11. CNS Delivery of Peptides Across the BBB Using the Dual-Artery in situ Brain Perfusion Model Ken A. Witt, Patrick T. Ronaldson, Karin E. Sandoval, and Thomas P. Davis 12. An Engineered Peptide Compound Platform Technology Incorporating Angiopep for Crossing the BBB Reinhard Gabathuler 13. Adeno-Associated Virus Mediated Gene Therapy in Ischemic Stroke Yongting Wang, Falei Yuan, and Guo-Yuan Yang 14. Use of Mesenchymal Stem Cells for Gene Delivery to Intracranial Glioma Sin-Soo Jeun, Seong Muk Kim, Jung Yeon Lim, and Chung Heon Ryu 15. Convection-Enhanced Drug Delivery to the Brain Dale Ding, Charles W. Kanaly, Martin L. Brady, Stephan Mittermeyer, Raghu Raghavan, and John H. Sampson

Blurb

Playing an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and administered systematically for targeted action, encounters a major challenge in the form of the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans. In addition to those methods, several overviews of innovative methods and their applications are presented in order to give a glimpse of the future of this research. As a volume in the successful Neuromethods series, this book presents its protocols with the kind of detailed description and implementation advice that is crucial for getting optimal results.

Authoritative and cutting-edge, Drug Delivery to the Central Nervous System serves as an ideal guide to scientists continuing to pursue knowledge of the delicate interactions between pharmaceuticals and the brain.