Drug Delivery Systems

ISBN-13: 9781588298911 / Angielski / Twarda / 2008 / 251 str.

Kewel K. Jain

Opis

Drug delivery systems (DDS) are an important component of drug development and therapeutics. The field is quite extensive and requires an encyclopedia to describe all the technologies. The aim of this book is to put together descriptions of important selective technologies used in DDS. Important drugs, new technologies such as nanoparticles, as well as important therapeutic applications, are taken into consideration in this selection. This book will be an important source of information for pharmaceutical scientists and pharmacologists working in the academia as well as in the industry. It has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS such as chemical engineering, protein engineering, gene therap y, and so on. This will be an important reference for executives in charge of research and development at several hundred companies that are developing drug delivery technologies. Kewal K. Jain, MD v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Drug Delivery Systems An Overview. . . . . . . . . . . . . . . . . . . . . . . . . . 1 Kewal K. Jain 2 The Role of the Adeno-Associated Virus Capsid in Gene Transfer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 Kim M. Van Vliet, Veronique Blouin, Nicole Brument, Mavis Agbandje-McKenna, and Richard O. Snyder 3 Delivering Small Interfering RNA for Novel Therapeutics . . . . . . . . . 93 Patrick Y. Lu and Martin C. Woodle 4 Catheters for Chronic Administration of Drugs into Brain Tissue. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 Michael Guarnieri, Benjamin S. Carson, Sr., and George I. Jallo 5 T ransdermal Drug Delivery Systems: Skin Perturbation Devices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 Marc B. Brown, Matthew J. Traynor, Gary P. Martin, and Franklin K."

Recenzje

"... a powerful reference that provides concise and systematic description of drug delivery technologies ..." - Doody's Book Review

Spis treści

Drug Delivery Systems Table of Contents Preface K. K. Jain Chapter 1. Drug delivery systems: an overview K. K. Jain Chapter 2 The Role of the Adeno-associated Virus Capsid in Gene Transfer R. O. Snyder Chapter 3 Delivering small interfering RNA for novel therapeutics Patrick Y. Lu Chapter 4 Catheters for Chronic Administration of Drugs into Brain Tissue Michael Guarnieri Chapter 5 Transdermal Drug Delivery Systems: Skin Peturbation Systems M. B. Brown Chapter 6 Controlling the Release of Proteins/Peptides via the Pulmonary Route Shoyele A. Sunday Chapter 7 Engineering Protein Particles for Pulmonary Delivery Shoyele A. Sunday Chapter 8 2B-Trans™ technology: targeted drug delivery across the blood-brain barrier Pieter Gaillard & Bert de Boer Chapter 9 Drug delivery in cancer using liposomes Crispin R Dass Chapter 10 pH-Responsive Nanoparticles for Cancer Drug Delivery Youqing Shen Chapter 11 Extended Release Oral Drug Delivery Technologies: Monolithic Matrix Systems SB Tiwari & A. Rajabi-Siahboomi

O autorze

The field of drug development and therapeutics can be overwhelmingly encyclopedic and vast. In this book, Dr. Kewal Jain and a team of experts select the most important, cutting-edge technologies used in drug delivery systems taking into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular Biology(TM) series format, offering readily reproducible results vital for pharmaceutical physicians and scientists. Concise and systematic, this book is a powerful reference tool for the hundreds of companies developing drug delivery technologies all around the world.

Blurb

The field of drug development and therapeutics can be overwhelmingly encyclopedic and vast. In Drug Delivery Systems, Dr. Kewal Jain and a team of experts select the most important, cutting-edge technologies used in drug delivery systems taking into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular Biology™ series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Concise and systematic, Drug Delivery Systems is a powerful reference tool for the hundreds of companies developing drug delivery technologies all around the world.