Drug Delivery: An Integrated Clinical and Engineering Approach

ISBN-13: 9780367867652 / Angielski / Miękka / 2019 / 602 str.

Yitzhak Rosen; Pablo Gurman; Noel Elman

Opis

The book integrates clinical and engineering aspects of drug delivery. It discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, and simulations, and describes the latest drug delivery advances involving nanotechnology, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasou

Spis treści

An Introduction of Key Concepts in Drug Delivery. An Introduction to Pharmacokinetics: From Conventional to Advanced Systemic Drug Delivery Systems. Transporters and Enzymes Targeted Prodrugs for Improved Oral Drug Delivery. Gastroretentive Delivery: Physicochemical, Biopharmaceutical, Technological and Regulatory Considerations. Invasive vs. Non-Invasive Delivery of Insulin. Artificial Pancreas Drug Delivery. Micro/Nano Devices for Drug Delivery. Microneedle-Mediated Vaccines. Application of Nanoparticle Tracking Analysis in Drug Delivery. Microsponges for Drug Delivery. Chitosan for Advancing Drug Delivery. Gene Delivery by Electroporation. Drug Delivery Systems for Infectious Diseases. Nanotechnology in Drug Delivery to Chronic Inflammatory Diseases. Intrathecal Drug Delivery. Cancer Stem Cell Drug Delivery. Cardiac Drug Delivery. Current Developments in Nano-Therapeutics for Airway Diseases. Intravitreal Drug Delivery. Drug Delivery in Obstetrics and Gynecology. Drug Delivery Systems: A Regulatory Perspective.

O autorze

Dr. Yitzhak Rosen, MD, is a graduate of the Tel Aviv University of Medicine. He is currently working in the Cardiology Department at SUNY Downstate Medical Center. He was previously a visiting research scientist at the Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology. He is also the president and CEO of Superior NanoBioSystems LLC, a biomedical company. He has served in the Israel Defense Forces (IDF) as a medical officer and physician in militarily active areas. He completed a medical internship at the Rabin Medical Center and has worked at the Oncology Institutes of both the Rabin and the Sheba Medical Centers in Israel. He has invented a microfluidic chip platform, funded by the Defense Advanced Research Projects Agency (DARPA), for effecting extremely rapid blood typing and cross-matching for mass casualties in collaboration with the MEMS and Nanotechnology Exchange. In addition, he is the inventor of several medical ultrasound technologies.

Dr. Pablo Gurman received his MD from Buenos Aires University School of Medicine in 2002, where he worked at the Pharmacology Department for 10 years. Dr. Gurman is currently the Chief Medical Officer of GearJump Technologies, a biotechnology company dedicated to develop innovative solutions to public health problems. Prior to this appointment, Dr. Gurman was a research scientist at the Materials Science and Engineering Department at the University of Texas-Dallas, as well as research collaborator at Dr. Elman’s group at the Institute for Soldiers Nanotechnologies at the Massachusetts Institute of Technology (MIT). Dr. Gurman was a visiting scientist at Argonne National Laboratory, where he worked under the artificial retina program. Dr. Gurman’s primary research interests involves micro and nanotechnology for medical diagnostics and therapeutics, controlled release technologies and biomaterials.

Dr. Noel Elman is the CEO and Founder of GearJump Te