Drug - Drug Interaction Studies of Prazosin

ISBN-13: 9783659125195 / Angielski / Miękka / 2012 / 272 str.

Shabana Naz Shah

Opis

In this work, we investigated the "in vitro" interactions of prazosin with frequently prescribed and co-administered drugs in simulated human body environments and thus to infer about the combination therapy. The interacting drugs selected for interaction with prazosin are ACE-inhibitors (captopril, enalapril and lisinopril), calcium channel blockers (amlodipine, diltiazem and verapamil), H2 receptor antagonists (cimetidine, famotidine and ranitidine), NSAIDs (diclofenac sodium, flurbiprofen, mefenamic acid, meloxicam and naproxen), statins (atorvastatin, rosuvastatin and simvastatin) and hydrated salts of essential and trace elements (magnesium, calcium, chromium, manganese, ferric, cobalt, nickel, copper, zinc and cadmium). These interactions were conducted in simulated gastric juice (pH 1), simulating full stomach (pH 4), simulating blood pH (pH 7.4) and simulating intestinal pH (pH 9) using UV/visible spectrophotometric and reversed phase high performance liquid chromatography (RP-HPLC).Prior to start the drug interaction studies, assay methods for the simultaneous quantitation of prazosin and interacting drugs were developed using UV/UV/visible spectrophotometer and RP-HPLC.

O autorze

Naz Shah, ShabanaDr. Shabana Naz Shah has obtained her PhD. Degree in Pharmaceutical Chemistry in October 2011 from University of Karachi. She has worked in Pfizer Pakistan Limited as an Assist. Manager of Training, Validation and Stability. She joined Parke-Davis & Co. ltd. in 1999. She is the author of several articles published in reputed journals.