Droplets of Life: Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation

ISBN-13: 9780128239674 / Angielski / Miękka / 2022

Vladimir N. Uversky

Spis treści

Part I: Introduction to Membrane-less Organelles and Biomolecular Condensates
1. Biophysical Principles of Liquid-Liquid Phase Separation
2. Major Structural Features of MLOs
3. Multiphase Complex Droplets
4. Biogenesis of MLOs and Protein Condensates
5. Techniques for the Detection and Analysis of LLPS and MLOs
6. LLPS and Origin of Life

Part II: Biology of Membrane-Less Organelles
1. Known Types of Membrane-Less Organelles and Biomolecular Condensates
2. Active Regulation Mechanisms
3. Control of Metabolic Pathways
4. Interactions and Interplay with Classical Membrane-Bound Organelles
5. LLPS and Chromatin Organization
6. MLOs and Cellular Fitness
7. Cellular Stress
8. Phase Separation in Bacteria
9. Phase Separation and Virus Replication Compartments

Part III: Pathological roles of LLPS
1. Neurodegenerative Diseases
2. Cancer
3. Cardiovascular Diseases
4. Infectious Diseases