Disease-Modifying Therapy in Vasculitides

ISBN-13: 9783764361471 / Angielski / Twarda / 2001 / 206 str.

Cees G. M. Kallenberg; Jan W. Cohen Tervaert; C. G. M. Kallenberg

Opis

Especially the past two decades have seen renewed interest in the vasc ulitides. In this volume an international expert group presents the cu rrent state of knowledge and concentrates on principles of immune modu lating therapy. Drawing from their work in rheumatology, nephrology, i nternal medicine, connective tissue disease and clinical immunology, t hey present new concepts in classificiation, diagnosis and pathophysio logy of the vasculitides. Evidence from experimental and clinical tria ls is reviewed, as well as the outlook for further research.

Spis treści

Systemic vasculitides, an introduction.- Standard therapeutic regimens for vasculitis.- Tumor necrosis factor (TNF) inhibition in the treatment of vasculitis.- Methotrexate as an alternative to classic immunosuppressive therapies.- Intravenous immunoglobulin as immuno-modifying treatment.- T-cell directed treatment: anti-thymocyte globulin.- New immunosuppressants: mycophenolate mofetil and 15-deoxyspergualin.- Interferon-? for the treatment of virus-related systemic vasculitides.- Autologous stem cell therapy for systemic vasculitis.- Prevention of relapsing disease in anti-neutrophil cytoplasmic antibody related necrotizing small-vessel vasculitis: the role for autoantibody guided and anti-bacterial treatment.