Discovery and Development of Neuroprotective Agents from Natural Products

ISBN-13: 9780128095935 / Angielski / Miękka / 2017 / 490 str.

Goutam Brahmachari

Opis

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer's disease, Parkinson's disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs.

• Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery
• Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases
• Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Recenzje

"The book should appeal to a broad audience with diverse backgrounds including chemistry, biology, pharmacy, and medicine. It can also be a valuable resource for researchers, academicians, and graduate students. In addition to enjoying the book's content, its readers will probably be able to identify viable research directions for the discovery and development of new and promising neuroprotective agents." --Ehab A. Abourashed, Journal of Natural Products Chemistry, Aug 2018

Spis treści

1. Natural Products as a source of neuroprotective agents for Parkinson's Disease 2. Discovery of neuroprotective antioxidants for the management of ischemic brain stroke 3. Discovery of biophenols for application in Alzheimer's Disease 4. Identification and Development of Naturally Occurring Anti-Inflammatory Steroid Analogues for Neuroprotection 5. Neuroprotective plant alkaloids: structure activity and synthetic analogues 6. Coumarin-based molecules as suitable models for developing new neuroprotective agents through structural modification 7. Phytochemistry and Pharmacology of Lycium barbarum L. and Schisandra chinensis (Turcz.) Baill" or "Neuroprotective phytochemicals of Lycium barbarum L. and Schisandra chinensis (Turcz.) Baill" 8. Neuroactive Components of Culinary and Medicinal Mushrooms with Potential to Mitigate Age Related Neurodegenerative Diseases

O autorze

Born on April 14, 1969 in Barala, a village in the district of Murshidabad (West Bengal, India), Goutam Brahmachari had his early education in his native place. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher Secondary Education (WBCHSE). Then he moved to Visva-Bharati (a Central University founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, he completed his master's in 1992 with a specialization in organic chemistry. After that, receiving his Ph.D. in 1997 in chemistry from the same university, he joined his alma mater the very next year and currently holds the position of a full professor of chemistry since 2011. The research interests of Prof. Brahmachari's group include natural products chemistry, synthetic organic chemistry, green chemistry, and the medicinal chemistry of natural and natural product-inspired synthetic molecules. With about 23 years of experience in teaching and research, he has produced 235 scientific publications, including original research papers, review articles, books, and invited book chapters in the field of natural products and green chemistry. He has already authored/edited 26 books published by internationally reputed major publishing houses, namely, Elsevier Science (The Netherlands), Academic Press (Oxford), Wiley-VCH (Germany), Alpha Science International (Oxford), De Gruyter (Germany), World Scientific (Singapore), CRC Press (Taylor & Francis Group, USA), Royal Society of Chemistry (Cambridge), etc. Prof. Brahmachari serves as a life member for the Indian Association for the Cultivation of Science (IACS), Indian Science Congress Association (ISCA), Kolkata, and Chemical Research Society of India (CRSI), Bangalore. He has also been serving as an associate editor for Current Green Chemistry.

Prof. Brahmachari serves as the founder series editor of Elsevier Book Series' Natural Product Drug Discovery. He is an elected fellow of the Royal Society of Chemistry, and a recipient of CRSI (Chemical Research Society of India) Bronze Medal, 2021 (contributions to research in chemistry), INSA (Indian National Science Academy) Teachers Award, 2019, Dr. Kalam Best Teaching Faculty Award, 2017, and Academic Brilliance Award, 2015 (Excellence in Research). Prof. Brahmachari was featured in the World's Top 2% Scientists (organic chemistry category) in 2020 and 2021 and the AD Scientific Index 2022 World Ranking of Scientists, 2022.