Part I: Space disruptions in a digitalising world 1. Definitions of space and grand challenges 2. Space dynamics: The role of digital disruptions 3. Space connectors: From physical to digital 4. Space routines: Digital elements as key building blocks Part II: Digital space reshaping transition processes 5. Digital space and the multi-level perspective 6. Digital space in the forefront of twin transition Part III: Digital space challenges and opportunities for regional development 7. Productivity 8. Resilience 9. Inclusion