Diagnosis and Management of Melanoma in Clinical Practice

ISBN-13: 9781447119272 / Angielski / Miękka / 2013 / 190 str.

Nigel Kirkham; Dennis W. K. Cotton; Roger C. Lallemand

Opis

In the last decade there has been no major clinical mono- graph on this increasingly common and difficult malignancy which is a killer of young people. The gap in the literature is now filled by this authoritative volumewhich will be essential reading for any body involved in the study or management of melanoma.

Spis treści

1 Epidemiology of Malignant Meloma.- Complexity and Dissonance.- Recall Bias.- Exposure.- Sex and Prognosis.- Age and the Neoplastic Process.- Rising Incidence Rates.- Rising Population Death Rates.- The Ozone Layer.- Prognosis as Function of Incidence.- Conclusion.- 2 Clinical Differential Diagnosis of Cutaneous Malignant Melanoma.- Patients at Risk of Developing Melanoma.- Lentigo Maligna Melanoma.- Superficial Spreading Malignant Melanoma.- Nodular Melanoma.- Acral or Acral Lentiginous Melanoma.- Aids to Clinical Diagnosis.- 3 Differential Diagnosis of Malignant Melanoma by Algorithm.- Freckles (Ephelides).- Seborrhoeic Warts.- Lentigo.- Lentigo Maligna (Hutchinson’s Freckle).- Junctional Naevus.- Superficial Spreading Malignant Melanoma.- Café au Lait Patch.- Plane Warts.- Skin Tags.- Dermatofibroma (Histiocytoma).- Seborrhoeic Wart (Basal Cell Papilloma).- Compound Naevus.- Nodular Malignant Melanoma.- Pigmented Basal Cell Carcinoma.- Blue Naevus.- Giant Comedone.- Solar Keratoses.- Bowen’s Disease.- Squamous Cell Carcinoma.- Basal Cell Carcinoma (Rodent Ulcer).- Irritated Seborrhoeic Wart.- Pyogenic Granuloma.- Spitz Naevus.- Campbell de Morgan Spot (Cherry Angioma).- Haemangioma.- 4 Clinical Diagnosis of Melanoma.- The Patient’s History.- Types of Malignant Melanoma and Presenting Features.- Accuracy in Diagnosis.- Aids to Clinical Diagnosis.- Image Analysis.- 5 Familial Melanoma.- Genetics.- Estimates of Risk of Melanoma.- Management of AMS Patients.- Non-melanoma Malignancy in the AMS Families.- Conclusions.- 6 The Histological Diagnosis of Cutaneous Melanoma.- Clinical Data.- Diagnostic Specimen.- Histological Features.- Melanoma.- Melanoma in Childhood.- Cutaneous Metastasis Versus (Second) Primary Melanoma.- Prognosis of Melanoma.- Routine Diagnostic Pathology Report of Melanoma.- 7 Histopathological Differential Diagnosis.- Benign Melanocytic Lesions with Histological Characteristics Normally Associated with Malignant Melanoma.- Dysplastic Naevi.- Conclusions.- 8 Prognostie Factors in Melanoma.- Localized Melanoma (Stage I).- Regional Nodal Melanoma (Stage IIIa).- Disseminated Melanoma (Stage IV).- 9 Surgery for Malignant Melanoma.- Diagnostic Surgery.- Definitive Primary Treatment.- Later Aesthetic Plastic Surgery.- Curative Surgery for Metastases.- Palliative Surgery.- 10 Isolated Limb Perfusion.- Techniques of Isolated Limb Perfusion.- Indications for Isolated Limb Perfusion.- Results of Therapeutic Isolated Limb Perfusion.- Prophylactic Isolated Limb Perfusion.- Conclusions.- 11 Systemic Treatment of Metastatic Malignant Melanoma.- Single Agent Regimes.- Combination Regimes.- Dose Intensification.- Biological Therapy.- Conclusion.- 12 Progress and Prospects for Therapeutic Targeting Strategies for Disseminated Melanoma.- Introduction: The Problem of Disseminated Melanoma.- Possible Targeting Strategies.- Experimental Targeted Antimelanoma Therapy.- Conclusion.- 13 Psychological Aspects of Malignant Melanoma.- Psychosocial Problems.- Inadequacy of Information.- Treatment of Side Effects.- Psychiatric Morbidity.- Personality and Malignant Melanoma.- Psychological Aftercare.