Diabetic Bone Disease: Basic and Translational Research and Clinical Applications

ISBN-13: 9783319353746 / Angielski / Miękka / 2016 / 241 str.

Beata Lecka-Czernik; John L. Fowlkes

Spis treści

Part I: Basic and Translational Research.- Bone Marrow Stem Cells and Bone Turnover in Diabetic Disease.- Growth Factors and Hormones in the Pathology and Treatment of Diabetic Osteopathy.- Energy Metabolism and Bone.- Non-enzyme Glycation and Collagen Cross-links in Diabetic Bone.- Part II: Biomechanics and Bone Quality.- Biomechanics Properties of Diabetic Bone.- Bone Quality in Diabetic Bone.- Imaging in Diabetic Bone.- Part III: Clinical Applications.- Skeletal Complications in Type 1 Diabetes.- Skeletal Complications in Type 2 Diabetes Mellitus.- Biomarkers of Diabetic Bone Disease.- Periodontal Bone Disease in Diabetics.- Bone Neuropathy and MIcrovasculature in Diabetes: Charcot Foot.- Drugs Used to Treat Diabetes and Their Effect on Bone.- Fracture Risk Calculations in Diabetes.

O autorze

Beata Lecka-Czernik, PhD, Professor, Department of Orthopedic Surgery, Center for Diabetes and Endocrine Research, University of Toledo Health Sciences Campus, Toledo, OH, USA

John L. Fowlkes, MD, James Hamlen Professor of Pediatrics, Vice-Chair for Research, Section Chief, Endocrinology and Diabetes, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA

Blurb

Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology to orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researchers and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.