Diabetes and Cardiovascular Disease: Etiology, Treatment, and Outcomes

ISBN-13: 9781461354963 / Angielski / Miękka / 2012 / 415 str.

Aubie Angel; Naranjan S. Dhalla; Grant N. Pierce

Opis

Diabetes and cardiovascular disease together account for the largest portion of health care spending compared to all other diseases in Western society. This work seeks to provide an understanding of the causes of diabetes and its cardiovascular complications. As this understanding becomes more widely appreciated, it will serve as a foundation for evidence-based care and wider acceptance of sound science. The International Conference on Diabetes and Cardiovascular Disease, held in Winnipeg, in June 1999, was organized to bring together a multi-disciplinary group of researchers dedicated to further knowledge amongst researchers, care givers, and the managers of the health system. The invited speakers submitted their works for publication, which serves as the basis for this book. Major themes include: epidemiology of diabetes mellitus, metabolic risk factors in diabetes and cardiovascular disease, hypertension in diabetes mellitus, cardiac function in diabetes, glycemic control and improved cardiovascular function, diabetes management, and endothelial function in diabetes.

Spis treści

Epidemiology and Genetic Determinants of Diabetes Mellitus. Type 2 Diabetes In Youth: A New Epidemic; H. Dean. Undiagnosed Diabetes; Burden and Significance in the Canadian Population; T.K. Young. Genes, Environment and Diabetes in Canadian Aboriginal Communities; R.A. Hegele. Diabetes in Sub-Saharan Africa; T.J. Aspray, N. Unwin. Coronary Heart Disease and Risk Factors in Asian Indians; M. Chandalia, P.C. Deedwania. Metabolic Risk Factors in Diabetes and Cardiovascular Disease. The Plasma Glucose Level - A Continuous Risk Factor for Vascular Disease in Both Diabetic and Non-Diabetic People; H.C. Gerstein. Modified Lipoproteins and Cardiovascular Risk; W. Aldahi, J. Frohlich. Advances in Lipid-Lowering Therapy in Atherosclerosis; J. Davignon. Homocysteine as a Risk Factor in Cardiovascular Disease; D.E.C. Cole. Endothelial Function and Diabetes. Endothelial Integrity and Repair; T.J. Lee , et al. Molecular Mechanisms of Endothelial Dysfunction in the Diabetic Heart; P.Rösen, et al. A Study of Vascular Wound Healing in a Rabbit Model of Type I Diabetes; N.K. Schiller, et al. Endothelins in the Microvasculature and Heart in Diabetes; S,Chakrabarti, et al. Diabetes and Endothelial Function: Implications for Coronary Angioplasty; T.J. Anderson. Hypertension and diabetes mellitus. The Effect of Hypertension in Diabetes; E.D. Burgess. The Diabetic Hypertensive (or Hypertensive Diabetic) - A Compelling Need to Optimize Blood Pressure; S.G. Carruthers. Left Ventricular Diastolic Dysfunction in Diabetic or Hypertensive Subjects: Role of Collagen Alterations; T.J. Regan, et al. Alterations in the Vascular Actions of Insulin in the Pathogenesis of Insulin Resistance and Hypertension; S. Verma, J.H. McNeill. Cardiac Hypertrophy in DiabetesPatients with and without Hypertension: Effects of Troglitazone, A Novel Antidiabetic Drug, on Diastolic Function; N. Makino, et al. Cost and Benefits of Blood Pressure Monitoring and Control; A. Chockalingam, N.R.C. Campbell. Cardiac lipid metabolism in diabetes. Malonyl COA Control of Fatty Acid Oxidation in the Diabetic Rat Heart; G.D. Lopaschuk. Alterations in 1,2-Diacylglycerols and Ceramides in Diabetic Rat Heart; K. Okumura, et al. Regulations of Myocardial Phospholipid N-Methylation by Insulin and Diabetes; S.W. Schaffer, M. Mozaffari. Reduction Of Phosphatidylinositol-4,5-Bisphosphate Mass In Heart Sarcolemma During Diabetic Cardiomyopathy; P.S. Tappia, et al. Tumor Necrosis Factor-&agr;, Sphingomyelinase and Ceramides Activate Tyrosine Kinase, P21ras and Phosphatidylinositol 3-Kinase: Implications for Glucose Transport and Insulin Resistance; A.N. Hanna, et al. Cardiac Function and Oxidative Stress in Diabetes. Antioxidants, Free Radical Stress and Diabetes; S.S. Rastogi, R.B. Singh. Oxidative Stress and Functional Deficit in Diabetic Cardiomyopathy; P.K. Singal. Ketosis and the Generation of Oxygen Radicals in Diabetes Mellitus; S.K. Jain, K. Kannan. Effect of Diabetes Mellitus on Hemodynamic and Cardiometabolic Correlates in Experimental Myocardial Infarction; S.K. Gupta, et al. Cardiac Function in Perfused Hearts From Diabetic Mice; D.D. Belke. Mg2+-Dependent Atpase Activity In Cardiac Myofibrils From The Insulin Resistant Jcr: La-Cp Rat; T. Misra. Cyclic Nucleotide Phosphodiesterase Families in Intracellular Signalling And Diabetes; C. Lugnier. Alterations in G-Protein-Linked Signal Transduction in Cardiovascular Smooth Muscle in Diabetes; M.B. Anand-Srivastava. Glycemic Control and Improved Cardiovascular Function. Mechanism of HDL Lowering in