Developmental and Reproductive Toxicology

ISBN-13: 9781493972067 / Angielski / Twarda / 2017 / 314 str.

Ali S. Faqi

Opis

This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands.

Spis treści

1. Metabolism and Drug-Drug Interaction in Pregnant Mother/Placenta/Fetus

            Ali S. Faqi and Karsten A. Holm

 

2. Critical Periods of Development in Teratology

            Padmanahban Rengasamy

 

3. Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Conducting Fertility, Embryo-Fetal Development, and Pre- and Postnatal Developmental Toxicology Studies

            Kevin H. Denny and Ali S. Faqi

 

4. A Developmental and Reproductive Toxicology Program for Chemical Registration

            Kamin J. Johnson, Bethany R. Hannas, Sue Marty, Carol L. Zablotny, Jessica LaRocca, Nicholas Ball, and Amanda

K. Andrus

 

5. The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility

            Sellappan Selvaraju, Meritxell Jodar, and Stephen A. Krawetz

 

6. Effects of Chemicals on Mammary Gland Development

            Adam Filgo and Ali S. Faqi

 

7. Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals

            Maia L. Green, Joshua Gamse, and Kimberly C. Brannen

 

8. Using the Alternative Model C. elegans in Reproductive and Developmental Toxicology Studies

            Daniel Ferreira, Yichang Chen, and Patrick Allard

 

9. High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays

            Quanwen Li, Yu Yang, Erica Louden, Elizabeth E. Puscheck, and Daniel A. Rappolee

Blurb

This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. 

Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resourc

e for researchers working in this vital field of study.