Developmental Aspects of the Lymphatic Vascular System

ISBN-13: 9783709116456 / Angielski / Miękka / 2013 / 204 str.

Friedemann Kiefer; Schulte Stefan

Opis

The book focuses on the lymphatic vascular system from a developmental biologist's point of view. It provides an overview on the many recent advances in understanding the development of lymphatic vessels, using advanced genetic models in conjunction with state of the art imaging. For each chapter a synopsis is provided, highlighting the main points in a concise manner. The book is intended for professors and researchers in vascular biology, angiogenesis research and developmental biology. It furthermore offers an excellent basis for entry level researchers and newcomers to this field, as well as for teachers, graduate students, advanced science and medical students.

Spis treści

Introduction by Friedemann Kiefer.- Transcriptional control of lymphatic endothelial cell type specification by Ying Yang and Guliermo Oliver.- Mechanosensing in developing lymphatic vessels by Lara Planas-Paz and Eckard Lammert.- Plasticity of airway lymphatics in development and disease by Li-Chin Yao and Donald M. McDonald.- Regulation of lymphatic vasculature by extracellular matrix by Sophie Lutter and Taija Makkinen.- Interplay of mechanotransduction, FOXC2, connexins and calcineurin signaling in lymphatic valve formation by Amélie Sabine and Tatiana V. Petrova.- Development of secondary lymphoid organs in relation to lymphatic vasculature by Serge A. van de Pavert and Reina Mebius.- Platelets in lymph vessel development and integrity by Steve P. Watson, Kate Lowe and Brenda A. Finney.- Interactions of immune cells and lymphatic vessels by Raghu P. Kataru, Yulia G. Lee and Gou-Young Koh.- Lymphatic vessels in the development of tissue and organ rejection by Denis Hos and Claus Cursiefen.- The role of neuropilin-1 / semaphorin 3A signaling in lymphatic vessel development and maturation by Alexandra M. Ochsenbein, Sinem Karaman, Giorgia Jurisic and Michael Detmar.- A fisheye view on lymphangiogenesis by Andreas van Impel and Stefan Schulte-Merker.- Visualization of lymphatic vessel development, growth and function by Cathrin Pollmann, René Hägerling, and Friedemann Kiefer.- Clinical disorders of primary malfunctioning of the lymphatic system by Carlo Bellini and Raoul C.M. Hennekam.- Subject index.

O autorze

Friedemann Kiefer is group leader at the Max Planck Institute for Molecular Biomedicine in Münster, Germany and Adjunct Professor at the Medical Faculty of the University of Münster. Stefan Schulte-Merker is group leader and Professor of Molecular Developmental Biology at the Hubrecht Institute in Utrecht, The Netherlands.

Blurb

For decades, lymphatic vessels were considered to be of “lesser significance” than blood vessels, and the fundamental importance of lymphatic vessels for physiological tissue homeostasis and their involvement in many pathological processes have only recently been fully appreciated. It is clear by now that all higher vertebrates possess a lymphatic vessel system, and that malfunctioning of the lymphatic vasculature has severe pathophysiological consequences.

Still, many central aspects of the developmental origin, growth control and regulation of lymphatic vessels are not sufficiently understood. This volume of “Advances in Anatomy, Embryology, and Cell Biology” focuses on the lymphatic vascular system from a developmental point of view, presenting exciting recent advances in elucidating the development and molecular control of lymphatic vessels. A collection of focused reviews, written by respected experts, describes ostensively how advanced genetic models and state-of-the-art imaging are being used to decipher the action of transcriptional programs, growth factors and matrix components in the regulation of lymphatic endothelial cell behavior. A synopsis is provided for each chapter, concisely highlighting the main points.

This collection provides both an ideal introduction to lymph vessel biology for newcomers and an invaluable resource for experts.